电针对实验性类风湿性关节炎大鼠海马中C-fos表达的影响  

Effect of Electroacupuncture on Expression of C- Fos in Hipocampus in the Rat with Experimental Rheuma- toid Arthritis

作　　者：许建阳[1] 冯琼[2] 赵仓焕[1] 宋开源[1] 

机构地区：[1]成都中医药大学,四川610075 [2]贵州省计生科研所

出　　处：《中国针灸》1998年第1期47-49,共3页Chinese Acupuncture & Moxibustion

摘　　要：以 Freund氏完全佐剂复制的实验性类风湿性关节炎 (RA) ,选用悬钟、昆仑穴 ,采用免疫组织化学等方法 ,观察电针 (EA)对实验性 RA海马中 c-fos表达的影响及其痛阈的变化 ,进一步探讨EA抗炎镇痛的中枢作用机制。结果显示电针对实验性 RA有确切的抗炎镇痛效应 ,可以抑制炎症痛模型的 FL I阳性细胞的表达。对探讨针刺对 RA的抗炎镇痛中枢作用机制具有一定的参考价值。In the ratof experimental rheumatoid arthritis de- veloped by Freund s complete adjuvant( RA) ,Xu- anzhong( GB39) and Kunlun( BL60 ) points received acupuncture and immunohistochemical method was adopted.Effects of electroacupuncture( EA) on expres- sion of c- fos in the hipocampus and pain threshold were observed for further probing into central mecha- nisms of anti- inflammatory and analgesic effects of EA.The results indicate that EA has defin ete antiin- flammatory and analgesic effects and influences ex- pression of c- fos in the hipocampus in the experimental RA.

关 键 词：电针 类风湿性关节炎 海马 c-fos类 

分 类 号：R259.932.2[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]