庆大霉素毫微球的体内抗菌活性研究  

In vivo antimicrobial activity of gentamicin polybutylcyanoacrylate nanoparticles

作　　者：张强[1,2,3] 廖工铁[1,2,3] 张淑华 

机构地区：[1]北京医科大学药学院药剂教研室 [2]华西医科大学药学院 [3]四川抗生素工业研究所药理室

出　　处：《中国药学杂志》1998年第1期21-24,共4页Chinese Pharmaceutical Journal

摘　　要：目的：观察庆大霉素与聚氰基丙烯酸正丁酯毫微球结合以后，其体内抗菌活性（特别是对细胞内感染）是否有所增加。方法：以鼠伤寒沙门杆菌感染的Ｃ５７ＢＬ／６ｊ小鼠为细胞内感染的动物模型，以小鼠存活率和器官组织中的活菌计数为指标，对庆大霉素聚氰基丙烯酸正丁酯毫微球的体内抗菌活性进行评价。结果：从存活率评价其治疗指数提高了１０倍。肝、脾、肾中活菌计数最低可降至庆大霉素溶液组的１／４２６，１／１４１和１／３０。结论：与庆大霉素溶液相比，庆大霉素毫微球明显提高了对伤寒沙门杆菌感染小鼠的治疗效果。OBJECTIVE: To observe whether the in vivo antimicrobial activity of gentamicin (specially in the intracellular infected animals) could be improved after associting with polybutylcyanoacrylate nanoparticles. METHOD: S. typhimurium infected C57BL/6j mice were chosen as the animal model of the intracellular infection, then the antimicrobial activity of gentamicin polycyanoeacrylate nanoparticles (GMNP) was evaluated by the mouse survival and the bacterial counts. RESULTS: By comparison with gentamicin solution (GMSol), the therapeutic index of GMNP based on mouse mortality was incrased by 10 fold, and the bacterial counts on liver, spleen and kidney could be as low as 1/426, 1/141 and 1/30 of GMSol treated groups respectively. CONCLUSION: By comparison with GMSol, in vivo antimicrobial activity of gentamicin over S. typhimurium infected C57BL/6j mice improved significantly after associting with polybutylcyanoacrylate nanoparticles.

关 键 词：庆大霉素 毫微球 抗菌活性 

分 类 号：R978.12[医药卫生—药品] R944.9[医药卫生—药学]