PLGA材料仿生改性的最新进展  

Latest advancement of poly lactic acid-glycolic acid (PLGA) materials bionic modification

作　　者：陈剑[1] 樊新[1] 周忠诚[1] 阮建明[1] 

机构地区：[1]中南大学粉末冶金国家重点实验室,长沙410083

出　　处：《粉末冶金材料科学与工程》2008年第6期323-329,共7页Materials Science and Engineering of Powder Metallurgy

基　　金：国家自然科学基金资助项目(50174059)

摘　　要：聚乳酸-乙交酯(PLGA)因具有优良的可降解性而在医用生物材料中得到了广泛应用,然而由于其表面缺乏细胞识别位点,以及存在亲水性和细胞亲和性不足等缺点,影响了细胞在其表面的粘附生长。为了得到生物功能和亲水性均较理想的聚乳酸类生物降解高分子,通过物理或者化学的方法在材料中引入胶原或多肽对其进行改性,赋予材料生物信号,以提高其生物功能,使其在组织工程支架的研究和临床应用更加广泛。该文主要对PLGA仿生改性的最新进展进行综述。Poly（lactic co-glycolic acid） （PLGA） has the ability of degrdation which leads this kind of material applied widely to medical biomaterials. However, because the PLGA material lacks of surface cell discrimination points and has poor ability ofhydrophilia and cellular affinity, surface cell adherent growing is poor. Therefore modification is needed in order to obtain ideal materials with fine bio-function and good hydrophilia, wherein physical and chemical method are used by introducing collagen and polypeptide endowing PLGA with bio-signal to improve the bio-property. After this kind of modification, PLGA will be applied extensively in tissue engineering study and clinic in the future. The present review facused on latest advancement of bionic modificationg for PLGA.

关 键 词：聚丙交酯-乙交酯(PLGA) 降解聚合物 亲水性 仿生改性 

分 类 号：R318.08[医药卫生—生物医学工程]