脱细胞衍生肌腱生物力学的实验研究  

Experimental Studies On Tendon Derivation Biomaterials Biomechanics

作　　者：曲彦隆[1] 侯树春[1] 姜晓明[1] 

机构地区：[1]哈尔滨医科大学附属一院骨科,黑龙江哈尔滨150001

出　　处：《中国伤残医学》2008年第6期2-4,共3页Chinese Journal of Trauma and Disability Medicine

基　　金：国家自然科学基金资助项目(30500508);黑龙江省攻关基金资助项目(QC03C20)

摘　　要：目的:探讨脱细胞处理后的衍生肌腱支架材料(tendon derivation biomaterials,TDBM)生物力学行为,为肌腱组织工程新型支架材料的应用提供依据。方法:将肌腱用生理盐水冲洗,洗去滑液。浸泡在10%甘油后,冻干处理。后经分丝处理,经一系列化学处理。进行形态应力松弛连续松弛谱、弹性模量(E)、屈服强度(F2)、断裂强度(F3)、屈服应力(d2)及断裂应力(d3)等检测。结果:TDBM的应力松弛连续松弛谱、弹性模量(E)、屈服强度(F2)、断裂强度(F3)、屈服应力(d2)及断裂应力(d3)与正常肌腱比较无显著差异(p>0.05)。TDBM材料屈服应变(e2)、断裂应变(e3)低于正常肌腱。结论:衍生肌腱支架材料具有与天然肌腱相似的生物力学性能,可作为肌腱细胞的有效载体应用于组织工程化肌腱的构建。Objective： To study the biomechanics of tendon derivation biomaterials （TDBM） of this three--dimension scaffold in tissue engineering. Methods.- tendon was freeze--dry after drop in 10% glycerol ,and devillicate. Elastic modulus of rock , yield strength, breaking strength, yield stress, crippling stress et, al. was detect. Results ： There was no significant difference be- tween TDBM and nature tendon in yield strength, breaking strength, yield stress（p〉0.05）. But yield strain ,break strain was lower than nature tendon. Conclusion ：TDBM show good biomeehanical character s because of more similarity of surface and com- ponent with tendon . It could be promising extracellular matrix scaffold for cell transplantation in tendon tissue engineering.

关 键 词：肌腱 生物材料 生物力学 组织工程 

分 类 号：R687.2[医药卫生—骨科学]