α_1受体阻滞剂对原发性高血压患者血压晨峰的影响  

The effect of α_1 acceptor retarder therapy on morning blood pressure surge in primary hypertensive patients

作　　者：赵胜利[1] 杨长永[2] 

机构地区：[1]中国化学工程第十一建设公司医院,开封475002 [2]河南大学护理学院,开封475004

出　　处：《中国实用神经疾病杂志》2008年第12期53-55,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨α1受体阻滞剂(特拉唑嗪)对原发性高血压患者血压晨峰的影响。方法选治疗未达标的原发性高血压患者26例,分别进行24h动态血压监测,观察其服用特拉唑嗪(每晚睡前2mg)前后血压晨峰的变化,并进行对比。结果服用特拉唑嗪治疗后,患者晨醒后半小时内血压较治疗前明显降低(P<0.01),且患者晨醒后半小时内血压与晨醒前最后一次血压的差值也较治疗前明显降低(P<0.01)。结论α1受体阻滞剂可以有效降低原发性高血压患者的血压晨峰。Objective To Study the effect of α1 acceptor retarder （Terazosin） therapy on morning blood pressure surge（MBPS） in primary hypertensive patients. Methods Twenty-six primary hypertensive patients that did not reach the standard were treated with Terazosin（2mg per night）, 24-hour ambulatory blood pressure monitoring was performed before and after treatment, and the influence of Terazosin on morning blood pressure surge was evaluated. Results After treatment, blood pressure decreased significantly corhpared with pre-treatment within hal/an hour after the awaking in the morning （P 〈0. 01） , and the difference value between blood pressure within half an hour after the awaking in the morning and the last one before awaking decreased significantly compared with pre-treatment （P〈0. 01）. Conclusion α1 aeeeptor retarder could effectively reduce morning blood pressure surge in primary hypertensive patients.

关 键 词：血压晨峰 特拉唑嗪 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]