N-硫脲基套索杯[4]冠醚与四硫脲基杯[4]芳烃的合成  

Synthesis of N-Thioureido Lariat Calix[4]crown and Calix[4]arene Tetrathioureido Derivatives

作　　者：郑小花[1] 杨发福[1] 唐富胜[1] 殷凤菊[1] 杨严心[1] 

机构地区：[1]福建师范大学化学与材料学院,福州350007

出　　处：《有机化学》2008年第12期2159-2161,共3页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20402002);福建省自然科学基金(No.2006J0155);福建省高校新世纪优秀人才支持计划资助项目

摘　　要：控制反应物的物质的量比,杯式对叔丁基杯[4]-1,3-二乙酸乙酯衍生物1与5或50倍二乙烯三胺反应,分别得到杯[4]氮杂冠醚2和开链的氮杂杯[4]芳烃衍生物3.化合物2和3进一步与异硫氰酸苯酯反应得到首例侧链含硫脲基的套索杯[4]氮杂冠醚4和含4个硫脲基的杯[4]芳烃衍生物5,产率为92%和87%.新化合物的结构与构象经元素分析、红外、质谱、核磁共振谱等表征证实.Under control of the molar ratio of reactants, calix[4]-aza-crown 2 and ring-opening azacalix[4]arene derivative 3 were obtained by reacting 5 or 50 times diethylene triamine with calix[4]arene ester derivative 1. Reacting compound 2 or 3 with phenyl isothiocyanate, novel N-thioureido lariat calix[4]crown 4 and calix[4]arene tetrathioureido derivative 5 were synthesized in yields of 92% and 87%, respectively. The structures and conformations of new compounds were characterized by elemental analyses, IR, ESI-MS, 1H NMR etc.

关 键 词：杯[4]芳烃 杯[4]冠醚 硫脲 套索 合成 

分 类 号：O621.3[理学—有机化学]