不同种类可吸收性外科缝线的体外降解性能评价  

Study on Degradability of the Absorbable Surgical Thread in vitro

作　　者：陆华[1] 孙皎[1] 丁婷婷[1] 顾国珍[1] 罗忠富[2] 

机构地区：[1]上海交通大学医学院附属第九人民医院上海生物材料研究测试中心,上海200023 [2]中科院上海有机化学研究所,上海200023

出　　处：《生物医学工程学进展》2008年第4期239-241,共3页Progress in Biomedical Engineering

基　　金：上海市重点学科(特色学科)建设项目资助(T0202)

摘　　要：目的研究3种不同种类的可吸收性缝线的体外降解性能,分析其体外降解产物。方法将3种可吸收性缝线分别按比例浸入Sorensen缓冲液中进行体外降解实验,设3个降解周期组,每组设3个重复,分别过滤分离试样、碎片和溶液,计算试样的质量损耗率。并对其体外降解产物进行定性定量分析。结果3种试样体外降解的质量损耗率均逐期增大;不同种类缝线的体外降解液成分不同,且其主要成份含量逐期增加。结论:不同种类的可吸收性缝线应采用不同的定性定量分析方法,根据产物推断缝线的生物安全性。Objective： To Study the degradability of there kinds of absorbable surgical threads in vitro, and analyze the products. Methods： The absorbable surgical threads were put into the Sorensen＇s cushion solution respectively in vitro. After 2w - 12w, the solutions were filtrated and the mass loss rates were calculated. Then analyzed the products from the solution. Results： The mass loss rate was increased every period. And the main product from the solution was different for every absorbable thread and its quantity was increased every period.Conclusion： The degradability in vitro can form a base of identification and quantification of degradability products from the different kinds of absorbable surgical threads. And it can be used to conclude the biological safety of the absorbable surgical threads.

关 键 词：可吸收缝线 体外 降解 

分 类 号：R608[医药卫生—外科学] R318.08[医药卫生—临床医学]