复方甘草酸苷注射液对慢性活动性乙型肝炎疗效评价及TNF-α和IL-6的影响  

Effect of compound glycyrrhizin injection on the treatment of patients with chronic hepatitis B and influence to serum TNF-α and IL-6

作　　者：王方[1] 焦栓林[1] 

机构地区：[1]中国人民解放军第153中心医院药剂科,河南郑州450042

出　　处：《中国医院药学杂志》2009年第1期49-51,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察复方甘草酸苷注射液对慢性活动性乙型肝炎的临床疗效,及其对血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的影响。方法:40例慢性活动性乙型肝炎患者给予复方甘草酸苷注射液,经过2～4周治疗后,检测患者的各项肝细胞功能指标、TNF-α和IL-6水平,以评价其临床疗效。利用双抗夹心酶免疫吸附法(ELISA)检测患者血清中TNF-α和IL-6水平。结果:接受复方甘草酸苷治疗后,患者的谷丙转氨酶、谷草转氨酶、胆红素均有显著降低,临床症状也明显改善。血清中的TNF-α和IL-6水平也显著下降(P<0.05)。结论:复方甘草酸苷治疗可有效地改善慢性活动性乙型肝炎患者的肝功能异常,控制症状发生,有效地降低促肝细胞炎症变化的细胞因子TNF-α和IL-6的分泌。OBJECTIVE To investigate the therapeutic effect of compound glycyrrhizin injection on the treatment of patients with chronic active hepatitis B, as well as on serum TNF-α and IL-6. METHODS Forty patients with chronic active hepatitis B were recruited and treated with compound glycyrrhizin injection iv blood samples were taken 2- 4 weeks after treatment. Hepatic function parameters, TNF-α and IL-6, and clinic response were analyzed in these patients. RESULTS After treatment with compound glycyrrhizin injection, liver function parameters such as serum ALT, AST and biliruhin were significantly decreased 244 weeks after treatment compared with those at the beginning of treatment. The treatment significantly improved clinical symptoms, and down-regulated the serum levels of TNF-α and IL6. CONCLUSION Compound glycyrrhizin injection is effective to treat chronic hepatitis B, improve the clinical symptoms, and down-regulate pro-inflammatory cytokines such as TNF-α and IL-6.

关 键 词：复方甘草酸苷 乙肝肝炎 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R969[医药卫生—药理学]