C-反应蛋白及心血管危险因素对高血压交互作用  

Interaction of C-reactive protein and cardiovascular risk factors on hypertension

作　　者：胡伟[1,2] 邢沈阳[3] 李永山[4] 佟伟军[1] 张显玉[5] 张永红[1] 

机构地区：[1]苏州大学放射医学与公共卫生学院流行病学教研室,215123 [2]江苏省淮安市疾病预防控制中心,223001 [3]吉林大学畜牧兽医学院 [4]内蒙古科左后旗疾病预防控制中心 [5]内蒙古奈曼旗疾病预防控制中心

出　　处：《中国公共卫生》2009年第1期9-12,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(30471484)

摘　　要：目的探讨C-反应蛋白与高血压的关系以及与其他心血管病危险因素的交互作用对高血压的影响。方法在蒙古族高血压现况调查基础上，采用病例对照研究方法，选择年龄≥30岁的高血压患者767人，对照762例，进行有关危险因素分析和身体指标的测量，采集血标本并进行血脂、血糖、胰岛素和C-反应蛋白含量检测。使用SPSS13．0软件进行统计分析。结果病例组C-反应蛋白含量为（2．10±0．83）mg／L，高于对照组的（1．80±0．77）mg／L，差异有统计学意义（P〈0．01）。按照C-反应蛋白含量将研究对象等分为〈1．40，1．40—1．83，1．84～2．53，≥2．54mg／L4组，以C-反应蛋白含量最低组作为参照，调整其他因素影响后，其他3组由低到高与高血压关联的OR值分别为1．144（95％CI=0．840—1．559），1．330（95％CI=0．970～1．824）和1．556（95％CI=1．116～2．172），存在高血压的患病危险随着C-反应蛋白升高而增高的趋势（χMH^2=7．397，P=0．007）。调整其他因素的影响后，吸烟、胰岛素抵抗与C-反应蛋白高含量的联合作用对高血压有正相加交互作用，交互效应超额相对危险度分别为0．799（P〈0．01）和0．651（P〈0．05）。结论C-反应蛋白水平与高血压患病危险相关联；吸烟、胰岛素抵抗与C-反应蛋白高含量对高血压的患病危险有交互作用。Objective To explore the relationship between C - reactive protein and hypertension, and the interaction of C - reactive protein and other cardiovascular risk factors on hypertension in Mongolian people. Methods On the basis of a prevalence survey,767 hypertensives and 762 normotensives aged ≥30 were selected as subjects to conduct the case -control study. All subjects were investigated for cigarette smoking, alcohol intake and the history of cardiovascular diseases. Subjects＇ body measurements, blood glucose,lipids,insulin and C- reactive protein were measured with standardized methods. All data were analyzed with SPSS software version 13.0 . Results The content of C - reactive protein （2. 10 ±0. 83 mg/ L） in cases was significantly higher than that of （1.80 ± 0.77 mg/L） in controls. After adjustment for other factors, subjects was divided into four groups according to the content of C - reactive protein. OR values of hypertention for three groups from low to high were 1. 144（0.840 -1. 559） ,1. 330（0.970- 1. 824）and 1. 556（ 1. 116 -2.172） ,respectively,compared to the group with the lowest content of C - reactive protein. There was a trend of hypertension prevalence increasing with the content of C - reactive protein （ χMH^2 = 7. 397, P = 0. 007 ）. There was a significant interaction between C - reactive protein and cigarette smoking and insulin resistance on hypertension after adjustment for other risk factors, and the relative exess risks due to the interaction（RERI） were 0.799（P〈0.01） and 0.651（P〈0.05） ,respectively. Conclusion High content of C - reactive protein was related with hypertension, and there was a trend of hypertension prevalence increasing with the content of C - reactive protein. There were interactions between C - reactive protein and cigarette smoking and insulin resistance on hypertension.

关 键 词：高血压 C-反应蛋白 危险因素 交互作用 

分 类 号：R54[医药卫生—心血管疾病] R544.1[医药卫生—内科学]