肾移植患者骨矿含量的测定及临床意义  

Determination of bone minerals in renal transplantation recipients and its clinical implication

作　　者：李香铁[1] 李慎勤[1] 刘少鸽[1] 王洪伟[1] 赫俊文 张海滨[1] 韩玮[1] 杨德安[1] 

机构地区：[1]济南军区总医院泌尿外科

出　　处：《中华器官移植杂志》1998年第1期4-6,共3页Chinese Journal of Organ Transplantation

摘　　要：测量了６４例肾移植患者移植前后的骨矿含量及骨钙素（ＢＧＰ）、甲状旁腺激素（ＰＴＨ）、血液生化的变化，以探讨它们的相互关系及临床意义。结果术前血肌酐（ＳＣｒ）、尿素氮（ＢＵＮ）、磷（Ｐ）、ＰＴＨ、ＢＧＰ为高水平，血钙（Ｃａ）低，骨矿含量（０．７７７±０．０１５ｇ／ｃｍ２）明显低于对照组（０．８１１±０．０３５ｇ／ｃｍ２）。术后肾功能正常者，ＳＣｒ、ＢＵＮ、Ｃａ、Ｐ及ＰＴＨ、ＢＧＰ均恢复正常，骨矿含量半年后恢复至对照组水平。提示慢性肾功能衰竭及血液透析期间存在明显钙磷代谢异常，严重骨营养不良；肾移植成功后骨矿含量恢复，纠正了肾性骨病；肾移植后骨矿含量低者，往往提示预后不良。The changes in levels of BMD, BGP, PTH, SCr, BUN, Ca2+, P3- were detected in 64 renal transplantation recipients to investigate their interactions and clinical implication. The results showed that serum SCr, BUN, PTH, BGP and P3- were in high level, and the levels of serum Ca2+ and BMD were obviously lower than those of control group before renal transplantation. After renal transplantation, SCr, BUN, Ca, P, PTH and BGP returned to normal levels, and BMD to the level of control group 6 months postoperation. It was suggested that the patients with chronic renal failure within the period of hemodialysis existed obviously metabolic disorder of Ca2+ and P3+, serious bony malnutrition. BMD might return to normal level after successful renal transplantation.

关 键 词：肾移植 骨疾病 矿物质 

分 类 号：R699.2[医药卫生—泌尿科学] R681[医药卫生—外科学]