肾衰方治疗维持性血液透析营养不良湿热证的临床研究  

Clinical Study of Shenshuai Prescription for Maintenance Hemodialysis Malnutrition with Damp-heat Syndrome

作　　者：吴立友[1] 饶家珍[1] 蒙向欣[1] 赵威[1] 于晓瑜[1] 徐云森[1] 

机构地区：[1]广州市中医医院肾病内科,广东广州510130

出　　处：《新中医》2009年第1期25-27,共3页New Chinese Medicine

摘　　要：目的:观察肾衰方治疗维持性血液透析(MHD)营养不良湿热证患者的疗效。方法:60例MHD营养不良湿热证患者随机分为治疗组30例,对照组30例。治疗组采用肾衰方治疗,对照组用复方α酮酸片。治疗前及治疗1月、2月、3月检测血清白蛋白(Alb)、前白蛋白、转铁蛋白、血红蛋白(Hb)及营养不良主要指标SGA评分、干体重、体质指数(body mass index,BMI)等指标。结果:治疗后治疗组治愈3例,显效6例,有效16例,总有效率为83.33%。对照组治愈1例,显效4例,有效17例,总有效率73.33%。2组治疗后总有效率比较,差异有显著性意义(P<0.05)。治疗组治疗1月后,临床症状评分与治疗前比较,差异有显著性意义(P<0.05),3月后与治疗前比较,有非常显著性意义(P<0.01),治疗3月后与对照组同时段比较,差异有非常显著性意义(P<0.01)。治疗组治疗2月后SGA评分与治疗前比较,差异有显著性意义(P<0.05),治疗3月后与治疗前比较,有非常显著性意义(P<0.01)。提示治疗组可以改善患者临床症状、升高SGA评分,疗效优于对照组。治疗组治疗后Alb、前白蛋白、转铁蛋白、Hb及BMI水平都有明显升高,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);其中除BMI以外,余指标与对照组同时段比较,差异也有显著性或非常显著性意义(P<0.05,P<0.01)。2组治疗后干体重及血清钾变化不显著。提示治疗组可改善患者的大多数营养指标。结论:肾衰方是治疗MDH营养不良湿热证患者的有效方剂。Objective:To observe the therapeutic effect of Shenshuai Prescription(SP)for maintenance bemodialysis(MHD)malnutrition with damp-beat syndrome.Methods:Sixty MHD malnutrition patients with damp-heat syndrome were equally randomized into 2 groups.The treat- ment group received SP,and the control group received compoundα-keto acid tablets.Serum lev- els of albumin(Alb),pre-albumin,transferrin,and hemoglobin(Hb)as well as the malnutri- tion parameters such as SGA scone,net body weight,body mass index(BMI)were examined be- fore treatment and after treatment for 1,2 and 3 month(s).Results:After treatment,3 patients were cured,6 markedly effective,16 effective,and the total effective raze was 83.33% in the treatment group;1 patient were cured,4 markedly effective,17 effective,and the total effective rate was 73.33% in the control group;the difference of total effective role was significant between the two groups(P<0.05).The clinical symptom score in the treatment group before treatment dif- fered from that after treatment for one month(P<0.05)and 3 months(P<0.01),and the dif- ference between the two groups after treatment for 3 months was also significant(P<0.01).SGA score in the treatment group before treatment differed from that after treatment for 2 months(P<0.05)and 3 months(P<0.01).Serum levels of Alb,pre-albumin,transferrin,Hb and BMI were increased in the treatment group after treatment(P<0.05 or P<0.01 compared with those before treatment and in the control group).The changes of net body weight and serum potassium lev- el were not significant.Conclusion:SP is effective for the tnearment of MHD malnutrition with damp-heat syndrome,

关 键 词：营养不良 血液透析 中医疗法 湿热 肾衰方 

分 类 号：R591[医药卫生—内科学]