维胃方对胃溃疡大鼠治疗作用的实验研究  

Experimental Study of Therapeutic Effect of Weiwei Prescription for Rats Gastric Ulcer

作　　者：卓冰帆[1] 刘晓伟[1] 肖卫平[1] 王炳卫[2] 贺红燕[1] 

机构地区：[1]南方医科大学中医药学院中医临床基础教研室,广东广州510515 [2]南方医科大学江都医院外科,广东广州510450

出　　处：《新中医》2009年第1期93-95,共3页New Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:30271567);广东省中医药局基金资助项目(编号:02102074)

摘　　要：目的:观察维胃方治疗实验性胃溃疡的疗效及其机制。方法:采用冰醋酸制备大鼠胃溃疡模型,各治疗组造模3d后予维胃方高、中、低剂量及雷尼替丁灌胃7d;并设正常组、模型组及对照组。处死大鼠检测胃液pH值、溃疡指数,测定胃黏膜前列腺素E_2(PGE_2)含量,并作组织病理学观察。结果:干预后雷尼替丁组、维胃方高、中、低剂量组溃疡指数明显降低,与模型组、对照组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);中剂量组降低较雷尼替丁组更明显(P<0.05)。维胃方各剂量组的溃疡抑制率均高于雷尼替丁组。雷尼替丁组、维胃方高、中、低剂量组胃液pH值明显升高,与对照组、模型组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。雷尼替丁组、维胃方高、中、低剂量组PGE_2含量升高,与模型组、时照组比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);低剂量组升高较雷尼替丁组更明显(P<0.05)。结论:维胃方对实验性胃溃疡具有明显修复治疗作用。其机制可能通过减少胃酸分泌,增加胃黏膜PGE_2含量,从而在抑制攻击因子和增强防御因子两个环节发挥作用。Objective:To observe the therapeutic effect of Weiwei Prescription(WP)for ex- perimental gastric ulcer(GU)and to explore its mechanism,Methods:GU rat models were in- ducnd by acetic acid.After modeling for 3 days,the rats were given high-,middle-and low- dose WP and ranitidine by gastric Savage for 7 days,respectively.After treatment,gastric mucosal prostaglandin E_2(PGE_2)content was detected and the gastric pathological changes were observed. Results:After treatment,the gastric ulcer index was lower in WP groups and ranitidine group than that in the model group and the normal control group(P<0.05 or P<0.01).The decrease of gastric ulcer index was obvious in the middle-dose WP group compared with the ranitidine group (P<0.05).Ulcer-inhibition rate in WP groups was higher than that in the ranitidine group. Gastric pH value and gastric mucosal PGE2 content were increased in WP groups and ranitidine group compared those in the model group and the normal control group(P<0.05 or P<0.01). The increase of gastric mucosal PGE_2 content in low-dose WP group was superior to that in the ranitidine group(P<0.05).Conclusion:WP can repair the experimental gastric ulcer,and its mechanism may be related with the reduction of secretion of gastric acid and increase of gastric mu- cosal PGE_2 content,and having an effect on inhibiting attack factors and enhancing defensive factors.

关 键 词：胃溃疡 维胃方 前列腺素E2 大鼠 实验研究 

分 类 号：R656.62[医药卫生—外科学]