经^(60)钴照射及裸鼠过渡的胚胎甲状旁腺同种移植四例  

Allotransplantation of fetus parathyroid after radiated with 60Co and cultured in nude rats

作　　者：刘仁斌[1] 陈国锐[1] 

机构地区：[1]中山医科大学附属第一医院外科

出　　处：《中华器官移植杂志》1998年第1期42-44,共3页Chinese Journal of Organ Transplantation

摘　　要：将６～８个月龄的新鲜死胎甲状旁腺用６Ｇｙ６０钴外照射，并在Ｂａｌｂ／ｃ裸鼠肾包膜下过渡１４天，然后切成０．５～１．０ｍｍ大小薄片移植给４例甲状旁腺功能低下症患者，受者仅术前１天和术后１～３天服用环孢素Ａ（剂量为２０～２５ｍｇ·ｋｇ－１／ｄ），以后不用任何免疫抑制剂。通过临床症状、体征、治疗的钙剂及ＶｉｔＤ制剂用量变化以及血钙、血甲状旁腺激素的追踪观察，以确定移植物的存活状况。结果表明，４例患者疗效均满意，其中３例疗效为优，１例疗效为良。对照我们过去的各种甲状旁腺移植方法，认为该方法是最理想的。Allotransplantation with fetus parathyroids was performed in 4 cases of hypoparathyroidism after the grafts had been radiated with 6 Gy of 60Co and cultured in Balb/c nude rats for 14 days. The recipients took 4 days of cyclosporine A (dose of 20￣25mg·kg-1/d), one day preoperation and 3 days postoperation. The patients were followed up for 5￣60 months. Traced observation on the patients' clinical symptoms and signs, the changes in the doses of Calcium and Vitamine D and in the levels of serum Calcium and parathyroid hormone was conducted to determine the grafts' survival. The results were satisfactory with all cases surviving for the followup period. It is considered that this method is much better than any we did previously.

关 键 词：甲状旁腺移植 甲状旁腺 机能减退 胚胎 同种移植 

分 类 号：R582.205[医药卫生—内分泌] R653.05[医药卫生—内科学]