Abnormal expression of PACAP gene in patients with myelodysplastic syndrome  

骨髓增生异常综合征患者骨髓细胞中PACAP基因的异常表达(英文)

作　　者：Stella Aprilia Ika 

机构地区：[1]The First Affiliated Hospital, Soochow University, Jiangsu Institute of Hematology, Leukemia Research Unit

出　　处：《The Chinese-German Journal of Clinical Oncology》2009年第1期55-58,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by grants from the National Natural Science Foundation of China (No. 30470733);the Natural Science Foundation of Jiangsu Provincial Government (No. BK2004040)

摘　　要：Objective： To explore the expression pattern of PACAP gene in patients with myelodysplastic syndrome （MDS）. Methods： The expression pattern of PACAP gene in CD34＋ cells from MDS patients was determined by microarray, confirmed in expanding samples by quantitative real-time PCR in bone marrow mononuolear cells. Results： The transcription of PACAP gene was found significantly down-regulated in patients with MDS in comparison with that in control samples, with a means of 220.1 in MDS-RA and 116.8 in MDS-RAEB （P 〈 0.05 ）. Conclusion： PACAP gene is expressed significantly lower in patients with MDS.

关 键 词：myelodysplastic syndrome （MDS） PACAP quantitative real-time PCR 

分 类 号：R55[医药卫生—血液循环系统疾病]