磁共振氢质子波谱测颅脑胶质瘤瘤周水肿的临床应用价值  

Clinical Application Value of Proton Magnetic Resonance Spectroscopy in Detecting Peritumoral Edema of Glioma

作　　者：张金华[1] 孟宪平[1] 冯东侠[2] 张怡璐[1] 陆亚萍[1] 姜歧涛[1] 王旭[1] 

机构地区：[1]江苏省江阴市人民医院,214400 [2]东南大学微侵袭神经外科研究所

出　　处：《职业与健康》2009年第1期9-11,共3页Occupation and Health

摘　　要：目的探讨氢质子磁共振波谱测颅脑胶质瘤瘤周水肿的临床应用价值。方法对共43例颅脑高、低级别肿瘤实体区、胶质瘤水肿区及对侧正常区域行磁共振氢质子波谱(1H-MRS)多体素检查,将距肿瘤强化外缘1cm以内区域划为近侧瘤周水肿区,1cm以外者为远侧瘤周水肿区,测各代谢物比值,即Cho/NAA、Cho/Cr、Cho/nCho。结果胶质瘤瘤周水肿区均获得了可评价性波谱图,高级别胶质瘤其Cho/NAA、Cho/Cr、Oho/nCho瘤周水肿值大于低级别胶质瘤(P<0.05),高级别胶质瘤近侧瘤周水肿值大于远侧瘤周水肿值(P<0.05)。胶质瘤近侧瘤周水肿值高于对侧正常组(P<0.01)。结论1H-MRS测颅脑胶质瘤瘤周水肿有助于原发肿瘤的诊断,可显示胶质瘤瘤周浸润,也有助于胶质瘤分级诊断。[Objective] To evaluate the clinical application value of 1H MRS in analyzing the parameters obtained from peritumoral edema. [Methods] 43 cases with high-grade and low-grade glioma underwent routine 1H MRS; the peritumoral edema was divided into two regions： the immediate peritumoral edema was defined within 1 cm distance from the outer enhancing tumor margin ; and the distant peritumoral one was defined as greater than 1 cm from the tumor; determination was made on the metabolic ratios including Cho/NAA, Cho/Cr and Cho/nCho. [Results] All data from spectroscopy in peritumoral edema are valid; the metabolic ratios of Cho/NAA, Cho/Gr and Cho/nCho in immediate peritumoral edema of patients with high-grade glioma were higher than that in the low-grade glioma （P 〈 0.05 ） ; the metabolic ratios of immediate edema surrounding glioma were higher than that of the distant edema （P〈0.05） and the normal （P〈0.01）. [Conclusion] The application of 1H MRS in determining peritumoral edema contributes to the diagnosis of primary carcinoma, it can demonstrate tumor infiltration of glioma, and is helpful for glioma grading diagnosis.

关 键 词：胶质瘤 瘤周水肿 氢质子波谱 

分 类 号：R445.5[医药卫生—影像医学与核医学]