蚕丝粉体改性聚氨酯材料的组织相容性  

The change of polyurenthane＇ s histocompatibility modified by silk micropowder

作　　者：欧阳晨曦[1] 王维慈[1] 徐卫林[2] 金毕[1] 李毅清[1] 裘法祖[3] 

机构地区：[1]华中科技大学同济医学院附属协和医院血管外科,武汉430022 [2]武汉科技学院湖北省纺织新材料及其应用重点实验室 [3]华中科技大学同济医学院附属同济医院外科

出　　处：《中华实验外科杂志》2009年第1期42-44,共3页Chinese Journal of Experimental Surgery

基　　金：基金项目：国家自然科学基金资助项目（50873079）;武汉市科技攻关计划重点资助项目（200860423212）

摘　　要：目的观察不同蚕丝粉体（sM）配比的改性聚氨酯（PU）材料人造血管的组织相容性。方法将PU与SM按照不同配比混合制成PU—SM薄膜。通过大鼠急性毒性实验、肌肉植入局部反应实验以及材料对细胞RNA合成影响实验，观察不同含量SM对改性PU材料组织相容性的影响。结果PU—SM复合材料经过适当的配比可有效的减低移植物对大鼠的急性毒性，且可降低局部炎症反应，较涤纶材料更为优良。SM比例为50％及70％时的PU—SM复合材料对细胞的数量和细胞总RNA基本不变，从分子水平说明SM配比为50％及70％时，PU—SM复合材料的组织相容性得到最大改善。结论经一定比例配比的SM改性PU材料可以改善PU的生物相容性。Objective To investigate the histocompatibility of the polyurenthane （PU） modified by different component ratio of silk mieropowder （SM）. Methods PU was combined with different ratio of SM to produce the thin PU-SM membranes. By acute toxicity test, test of local histological response by material implanted in muscle and the research on the effects of the material RNA synthesis, the histocompatibility of PU modified by different ratio of SM was assayed. Results Proper ratio of PU-SM material could effectively alleviate the acute toxicity to mice, and reduce the local tissue inflammatory reaction, and histoeompatibility of PU-SM was superior to Dacron. PU-SM materials with 50% and 70% ratio of SM had almost no influence on the cell number and total RNA. Conclusion PU modified with proper ratio of SM can improve PU＇ s histocompatibility.

关 键 词：人造血管 聚氨酯 蚕丝粉体 组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程] R944.5[医药卫生—基础医学]