不同剂量He-Ne激光照射对骨折愈合影响的实验研究  

Stimulating Effect of He-Ne Laser Irradiation on Bone Fracture Healing in Rabbits

作　　者：耿建华[1] 陈英茂[1] 魏晓芬[1] 朱彦明[1] 孟照耀 李景印[1] 

机构地区：[1]河北省承德医学院

出　　处：《中国激光医学杂志》1998年第1期34-37,共4页Chinese Journal of Laser Medicine & Surgery

基　　金：河北省科委攻关课题

摘　　要：为了研究不同剂量的Ｈｅ－Ｎｅ激光照射对骨折愈合的作用，确定促进与抑制剂量范围及估计最佳剂量值，研究三个不同剂量的Ｈｅ－Ｎｅ激光照射对骨折愈合的作用。将３２只新西兰家兔的左桡骨造成实验性骨折，分为４组，分别以能量密度为３６．０Ｊ／ｃｍ２（Ａ组）、１６．８Ｊ／ｃｍ２（Ｂ组）、４．８Ｊ／ｃｍ２（Ｃ组）和０．０Ｊ／ｃｍ２（对照组）的Ｈｅ－Ｎｅ激光照射骨折部位，每日１次，共１０次。拍摄骨折后３０天的Ｘ线片，测定骨折后３５天愈合骨的生物力学抗扭强度及单位质量骨痂钙含量。结果：Ｂ组和Ｃ组各指标均显著优于对照组，且Ｂ组显著优于Ｃ组；对照组显著优于Ａ组。表明：１６．８Ｊ／ｃｍ２和４．８Ｊ／ｃｍ２的Ｈｅ－Ｎｅ激光照射促进骨折愈合，而１６．８Ｊ／ｃｍ２效果更佳；３６．０Ｊ／ｃｍ２的Ｈｅ－Ｎｅ激光照射抑制骨折愈合。his study aims to investigate the effects of He-Ne laser irradiation on bone fracture healing at various doses, to determine the range of stimulating and inhibiting doses and to estimate the optimal dose. The effect of three energy doses of He-Ne laser irradiation on fracture healing in New Zealand rabbits were studied. 32 rabbits were divided into four groups and received 360 J/cm2, 168 J/cm2, 48 J/cm2, and 00 J/cm2 of HeNe laser irradiation in groups A, B, C, and D, respectively. The group D served as the control. Three indices, roentgenogram, biomechanical antitorsion strength and calcium content in callus were examined. The results showed that all indices in group B and group C were significantly higher than those in control group, the indices in group B were significantly higher than those in group C, and the indices in control group were significantly higher than those in group A. The findings suggested that He-Ne laser irradiation at 168 J/cm2 and 48 J/cm2 stimulated the fracture healing process, 168 J/cm2 was the best of the three energy densities used, while He-Ne laser irradiation at 360 J/cm2 inhibited the fracture healing.

关 键 词：骨折愈合 生物刺激 激光疗法 

分 类 号：R683.05[医药卫生—骨科学]