阻遏诱变剂镉在海洋生物中传递的物质及作用机理的研究(Ⅲ)海参提取液  

STUDY OF THE PROHIBITOR AGAINST TRANSFER OF Cd^2+ ——MUTAGEN IN MARINE ORGANISMS AND ITS MECHANISM Ⅲ. SEA-CUCUMBER t

作　　者：林光恒[1] 刘明星[1] 孙国琼[1] 

机构地区：[1]中国科学院海洋研究所

出　　处：《癌变．畸变．突变》1998年第1期1-4,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金

摘　　要：海参是我国民间食疗的重要补品，具健体壮阳之功效。海参皂甙（Ｈｏｌｏｔｈｕｒｉｎ）是海参水提取物的主要成分。本文报道了海参水提取物在中国对虾（Ｐｅｎａｅｕｓｏｒｉｅｎｔａｌｉｓ）体内具有阻遏诱变剂镉被对虾肌体吸收和积累的作用，经化学分析和遗传毒性分析均一致证明该提取物是诱变剂镉的有效阻遏剂或抑制剂，能有效地提高对虾机体抗毒性作用。Seacucumber is rich in nutrients which has been considered by Chinese to be a nourishing seafood. It has the efficacy in nourishing the kidney and strengthening the human body. Holothurin is the main constituent in seacucumber abstract with water. Present paper reports its activity of prohibiting Cd^2+ mutagen to be absorbed and accumulated by the prawn body (Penaeus orientalis) and decreasing its genotoxicity. All those were verified by chemical analysis with PRGP and mutagenic test with TradMCN.

关 键 词：海参提取液 镉 透发剂 中国对虾 抗癌作用 

分 类 号：R979.1[医药卫生—药品] R931.77[医药卫生—药学]