三尖杉磷碱溴代分离紫杉醇的方法  

The methods of separation cephalomannine from paclitaxel through bromination

作　　者：郑玲[1] 刘玉华[1] 严明娟[1] 

机构地区：[1]云南省药物依赖防治研究所,650228

出　　处：《中国现代药物应用》2009年第2期27-27,共1页Chinese Journal of Modern Drug Application

摘　　要：目的从不同紫杉醇含量的原料中分离三尖杉磷碱。方法对三尖杉磷碱进行溴代反应。结果三尖杉磷碱与紫杉醇的Rf值大大拉开,有利于紫杉醇的分离纯化。结论通过溴代反应,可从不同紫杉醇含量的原料中分离三尖杉磷碱。Objective To separate cephalomannine from different content＇s paclitaxel of raw materials. Methods Through a methods of bromination to cephalomannine. Results The Rf greatly raised,that＇s helpful to the separation and purification of paclitaxel Conclusion Through the method of bromination,we can separate cephalomannine from paclitaxel, applied to different content＇s paclitaxel of raw materials.

关 键 词：三尖杉磷碱 紫杉醇 溴代 分离 

分 类 号：TQ464[化学工程—制药化工]