异甘草酸镁对急性四氯化碳肝损伤小鼠保护作用的研究  

Protective Effect of Magnesium Isoglycyrrhizinate on Acute Hepatic Injury induced by CCl_4 in Mice

作　　者：顾新[1,2] 董丽萍[1] 刘宇宸[1] 于锋[1] 

机构地区：[1]中国药科大学临床药学教研室,南京210009 [2]南京大学医学院附属鼓楼医院药剂科

出　　处：《中国药师》2009年第1期37-39,共3页China Pharmacist

摘　　要：目的:研究异甘草酸镁(magnesium isoglycyrrhizinate,MgIG)对急性四氯化碳(CCl_4)肝损伤小鼠的保护作用及其机制。方法:采用CCl_4诱导的小鼠急性肝损伤模型,分别设空白组,模型组,阳性药组,MgIG低剂量组,MgIG中剂量组,MgIG高剂量组。测血清ALT、AST和组织匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)含量,观察MgIG等各给药组对肝损伤的保护作用。HE染色,采用光镜对各组肝脏作病理检查。结果:MgIG能显著降低小鼠血清中升高的ALT、AST水平和过氧化物终产物MDA的含量,增加SOD活力。病理学检查可见MgIG高剂量组细胞变性、坏死及炎细胞浸润明显减轻,病变降低。结论:MgIG对CCl_4所致小鼠急性化学性肝损伤具有保护作用,其机制与其抗自由基、提高抗氧化酶的活性有关。To investigate the protective effect of MglG on acute hepatic injury in mice induced by CCl4. Method： The acute hepatic injury model of mice was induced by CCl4. The mice were divided into control group, patho-model group, MgIG high, middle and low dose group, bifendate group. The changes of activity of ALT, AST in serum and MDA, SOD content in liver tissue were measured. Then the pathologic change of liver tissue was examined under light microscope by HE staining. Result： MgIG could decrease the activities of ALT, AST in serum and MDA content in liver tissue; and increase the SOD content in liver tissue. Conclusion： MgIG has protective function against acute liver injury in mice induced by CCl4.

关 键 词：异甘草酸镁 四氯化碳 小鼠 急性肝损伤 

分 类 号：R965.1[医药卫生—药理学]