氨茶碱与呋塞米注射液的配伍稳定性  

Stability of Aminophylline Injection and Furosemide injection in Compatibility Solutions

作　　者：徐帆[1] 冯恩富[1] 赵星星[2] 陆丽[2] 李艳[3] 

机构地区：[1]成都军区昆明总医院,昆明650032 [2]云南大理学院 [3]昆明医学院

出　　处：《中国药师》2009年第1期86-88,共3页China Pharmacist

摘　　要：目的:考查氨茶碱、呋塞米注射液的配伍稳定性。方法:观察及测定2种注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温放置8h内的外观、不溶性微粒及pH,并采用高效液相色谱法测定其含量。结果:室温8h内,氨茶碱与呋塞米在0.9%氯化钠注射液中的外观、pH、微粒、含量均无明显变化;在5%葡萄糖注射液中6h左右溶液颜色略有变化,pH、微粒、含量则无明显变化。结论:氨茶碱、呋塞米注射液可以在0.9%氯化钠注射液中配伍使用。To study the compatible stability of aminophylline injection and furosemide injection. Method： The changes in appearance, particles and pH value of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection within 8 hours at ambient temperature were observed. The concentrations of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection were determined by HPLC-UV within 8 hours. Result： Within 8 hours at room temperature, no obvious changes in the pH value,particle number and contents of both drugs in 0.9% sodium chloride injection were demonstrated. The solution in glucose injection, however, had a little change in color after 6 hour and no obvious changes in the pH value, particle number and contents. Conclusion ： Aminophylline injection was shown to be compatible with furosemide injection in 0.9% sodium chloride injection.

关 键 词：氨茶碱 呋塞米 配伍 高效液相色谱法 

分 类 号：R942[医药卫生—药剂学]