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作 者:杨飞[1] 李芳[2] 焦海胜[2] 赵慧[2] 周素琴[2] 张鸿燕[2] 邱雯[2]
机构地区:[1]兰州大学药学院,兰州市730000 [2]兰州大学第二医院药剂科,兰州市730030
出 处:《中国药房》2009年第1期50-52,共3页China Pharmacy
摘 要:目的:制备秋水仙碱醇质体凝胶并建立其质量控制方法。方法:以秋水仙碱为主药,采用注入法制备醇质体,研和法制备醇质体凝胶;采用紫外分光光度法测定其中秋水仙碱的含量,并测定包封率。结果:所制制剂为淡黄色透明凝胶,鉴别项符合2005年版《中国药典》中的相关规定;秋水仙碱检测浓度的线性范围为7.224~18.06μg·mL-1,平均回收率为102.63%(RSD=0.687%,n=3);包封率为(56.99±1.35)%。结论:本制剂制备工艺简便可行,质量稳定可控。OBJECTIVE: To prepare colchicines ethosomes gel and to establish its quality control method. METHODS: Colchicine ethosomes were prepared by injection method with colchicines as chief agent, and the ehosome gel was prepared using mixing method. The content of colchicine was determined by UV- spectrometry and its encapsulation efficiency was determined. RESULTS: The preparation was yellowish transparent gel, with its property identification in line with the standard specified in Chinese Pharmacopeia (2005 Edition) . The linear range of colchicine was 7.224-18.06μg · mL ^-1 the average recovery was 102.63% (RSD = 0.687%, n = 3), and the encapsulation efficiency was (56.99± 1.35)%. CONCLUSION: This gel is feasible in preparation technique, stable and controllable in quality.
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