大黄与乌司他丁合用治疗严重多发伤后急性呼吸窘迫综合征疗效观察  

Clinical Study of Rhubarn and Ulinastatin in the Treatment of Acute Respiratiory Distress Syndrome after Severe Multiple Trauma

作　　者：翁伟建[1] 李晓峰[1] 张铭熙 林颖华 

机构地区：[1]兰州大学第一医院,兰州730000 [2]广东省中西医结合医院,佛山528200

出　　处：《中国中医急症》2009年第1期11-13,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的评价大黄加乌司他丁对严重多发伤后急性呼吸窘迫综合征(ARDS)的治疗作用。方法80例严重多发伤患者随机分为治疗组与对照组各40例,治疗组从入院急诊术后第1日开始,每日给中药大黄胶囊,每日3次,连续用药6d,并且于创伤后(入院急诊术前)及术后静滴乌司他丁30万u,每12小时1次,连续用药6d;对照组仅予常规治疗。分别观察两组伤者的呼吸频率(RR)、氧分压(PaO2)、二氧化碳分压(PaCO2)、氧合指数(PaO2/FiO2),并测定血浆TNF-α、IL-2、IL-6以及IL-8等细胞因子及炎性介质含量的变化。结果治疗组肺各项指标改善明显优于对照组;同时术后血浆TNF-α、IL-2、IL-6及IL-8水平低于对照组。结论大黄与乌司他丁合用对严重多发伤患者的肺功能有较好的保护作用,能减少机体对创伤侵袭的反应。Objective： To evaluat the effect of rhubarb and ulinastatin in the treatment and prevention of acute respiratiory distress syndrome after severe multiple trauma. Methods： 80 patients of severe multiple trauma were randomly divided into control group（40 cases） and treatment group（40 cases） . The rhubarb was given for 6d in the treatment group. The nlinastatin of 0.6 million unit was used by iv gtt. per day in the treatment group from the day after injury（before operation） last for 6d. The control group was only given the routine treatment. The RR, PaO2, PaCO2, PaCO2/FiO2, TNF - α, cell factor were determined in both groups. Results： Postoperative indexes of lung function of therapeutic group was obviously better than the control group and the TNF - α, IL - 2, IL - 6, IL - 8 was less than the control group. Conclusion： The rhubarb and ulinastatin can protect the lung function and reduce the traumatic reaction for patients with severe multiple trauma.

关 键 词：严重多发伤 急性呼吸窘迫综合征 大黄 乌司他丁 

分 类 号：R563.8[医药卫生—呼吸系统]