二氧化硒氧化3-甲基吡啶合成烟酸的研究  

Study on the synthesis of nicotinic acid with 3-picoline oxided by selenium dioxide

作　　者：蒋丽红[1] 王亚明[1] 吴浩[1] 

机构地区：[1]昆明理工大学化学工程学院,云南昆明650224

出　　处：《云南大学学报（自然科学版）》2009年第1期65-68,73,共5页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省应用基础研究计划面上项目资助(2006B0014Q)

摘　　要：采用二氧化硒为氧化剂,以3-甲基吡啶为原料经液相氧化法合成烟酸,适宜的反应条件为:3-甲基吡啶与二氧化硒摩尔比为1∶1.6,3-甲基吡啶浓度2 mol/L,反应温度130℃,反应时间120 min,此条件下产品收率达到40.3%,所得产品达到国家GB14757—93标准.The synthesis of nicotinic acid with 3 - picoline oxided by selenium dioxide was studied. The suitable process conditions were obtained ： the mole ratio of 3 - picoline/selenium dioxide was i ： 1.6, the concentration of 3 -picoline was 2 mol/L,reaction tempaerature was 130 ℃, reaction time was 120 min. In the condition,the yield of product was up to 40.3% ,and the quality of product met the criterion of GB14757-93.

关 键 词：二氧化硒 3-甲基吡啶 氧化 烟酸 合成 

分 类 号：R977.2[医药卫生—药品]