老年糖尿病人脂蛋白(a)的变化及其临床意义  

THE SIGNIFICANCE OF CHANGES OF SERUM LIPOPROTEIN(a) IN SENILE PATIENTS WITH DIABETES MELLITUS

作　　者：赵文娟[1,2] 林楠[1,2] 袁鹰[1,2] 付正菊[1,2] 

机构地区：[1]青岛医学院附属医院内分泌科 [2]青岛市人民医院内科

出　　处：《青岛医学院学报》1998年第1期28-29,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨老年糖尿病病人脂蛋白（ａ）的变化及其临床意义。②方法测定５４例老年糖尿病病人血清脂蛋白（ａ）［ｌｐ（ａ）］水平，并与其他血脂成分进行相关性分析。③结果老年糖尿病各组病人ｌｐ（ａ）水平均高于对照组（Ｆ＝４２．３，ｑ＝４．８～１５．５，Ｐ均＜０．０１）；并发心脑血管疾病和糖尿病肾病病人组显著高于无并发症组（Ｆ＝４２．３，ｑ＝３．８，１０．０，Ｐ＜０．０５，０．０１）。ｌｐ（ａ）与其它各血脂成分间均无相关性（ｒ＝－０．１２～０．１７，Ｐ均＞０．０５）。④结论ｌｐ（ａ）升高可能是老年糖尿病病人早发、易发心脑血管疾病的独立危险因素，且可能在糖尿病肾病。Objective To observe the changes of serum lipoprotein (a) in senile patients with diabetes mellitus (DM). Methods The serum lp(a) of 54 cases of DM were measured and their correlations with other serum lipid constituents were studied. Results The levels of lp(a) in senile patients was higher than those of the control group( F=42.3,q=4.8～ 15.5,P <0.01). While those complicated with cadiovascular disease, cerebrovascular and nephropathic disease presented with higher levels of lp(a) than those without the complications( F=42.3,q=3.8, 10.0,P <0.05,0.01). However, there was no relationship between the lp(a) and other lipid constituents( r=-0.12～0.17,P >0.05). Conclusion lp(a) was an independent risk factor for predisposition of senile diabetic patients to cardiocerebravascular diseases and played an important role in the pathogenesis of nephropathy and renal damage.

关 键 词：脂蛋白 糖尿病 老年人 

分 类 号：R587.104[医药卫生—内分泌] R446.112[医药卫生—内科学]