远洋船员血浆超氧化物歧化酶活力和丙二醛含量的检测  

DETECTION OF SOD ACTIVITY AND MDA CONTENT IN PLASMA OF OCEAN SAILORS

作　　者：徐珞[1] 徐建林[1] 陶尚敏[1] 周颖斌[1] 唐明[1] 

机构地区：[1]青岛医学院生理学教研室

出　　处：《青岛医学院学报》1998年第1期43-44,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的观察中国远洋船员血浆超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量的改变。②方法采用分光光度比色法检测５３例远洋船员血浆ＳＯＤ活力和ＭＤＡ含量变化。③结果中国远洋船员血浆ＳＯＤ活力比陆地工作人群明显降低（ｔ＝７．９３，Ｐ＜０．００１）；而血浆ＭＤＡ含量则显著增高（ｔ＝３．５１，Ｐ＜０．００１）；连续海上航行大于１８０ｄ者的血浆ＳＯＤ活力明显低于连续海上航行小于１８０ｄ者（ｔ＝７．９１，Ｐ＜０．００１），而血浆ＭＤＡ含量比连续航行小于１８０ｄ者明显升高（ｔ＝２．４１，Ｐ＜０．０５）。Objective To study the changes of superoxide dismutase (SOD) activity and malonic dialdehyde content(MDA) in plasma of ocean sailors. Methods SOD and MDA were assayed with spectrophotometry. Results The activity of SOD was significantly decreased compared with that of the control group ( t=7.93, P <0.001 ); while the contents MDA was significantly increased ( t=3.15, P <0.001). For sailors who had been sailing for over 180 days the SOD activity was significantly decreased compared with that of the sailors who had been sailing for less than 180 days( t=7.91, P <0.001), but the content of MDA was significantly increased ( t=2.41,P <0.05). Conclusion The ability of antioxidation was decreased in the Chinese ocean sailors.

关 键 词：血浆 超氧化物歧化酶 过氧化物脂质 航海医学 

分 类 号：R832[医药卫生—航空、航天与航海医学]