外源性雌激素对小鼠子宫b-FGF和TGF-β_1表达的影响  

Effect of Estradiol on the Expression of b-FGF and TGF-β_1 in Mouse Uterus

作　　者：滑静[1] 杨佐君[1] 万善霞[1] 张淑萍[1] 谢邦文[1] 

机构地区：[1]北京农学院生物技术系,北京102206

出　　处：《北京农学院学报》2008年第4期1-4,共4页Journal of Beijing University of Agriculture

基　　金：北京市教委人才强教资助项目(项目编号:PXM2007-014207-044539)

摘　　要：为探明雌激素对小鼠子宫碱性成纤维细胞生长因子(b-FGF)和转化生长因子-β1(TGF-β1)表达的影响,应用免疫组化染色观察雌激素对小鼠子宫b-FGF和TGF-β1表达的影响。结果表明,随着外源性雌激素的介入,子宫基质细胞中b-FGF和TGF-β1阳性着色反应增强,腺上皮则减弱。提示外源性雌激素对小鼠子宫不同类型细胞中b-FGF和TGF-β的表达有不同的调节作用,此调节可能参与小鼠胚泡着床过程。The effect of estrogen on the expression of b-fibroblast growth factor （b-FGF） and transforming growth factor Betal （TGF-β1） in mouse uterus was studied to clarify the biological effects of b-FGF and TGF-β1 on blastocyst implantation in mice. Strong immunostaining for b-FGF and TGF-β1 was increasingly expressed in the stromal cells, but decreasingly expressed in glandular epithelium with the increase of the estrogen dose or. Conclusions： Estrogen had effect on the expression of b-FGF and TGF-β1 in mouse endometrium, including stimulating the expression of b-FGF and TGF-β1 in the stroma-cell or-inhibiting their expression in glandular epithelium. Thus, b-FGF and TGF-β1 were supposed to play an important role through its receptor during the recovery of the stroma-cell and the differentiation and proliferation in mouse uterus cells.

关 键 词：雌二醇 碱性成纤维细胞生长因子 转化生长因子 小鼠子宫 

分 类 号：S852.1[农业科学—基础兽医学]