补体因子H基因^(1277)T/C多态性与早发冠心病的相关性研究  

The relationship of complement factor H gene ^(1277)T/C polymorphism and premature coronary heart disease

作　　者：孙彩琴[1] 陈忠[2] 马根山[2] 

机构地区：[1]靖江市人民医院心内科,江苏214500 [2]东南大学附属中大医院

出　　处：《交通医学》2008年第6期606-608,共3页Medical Journal of Communications

基　　金：江苏省社会发展计划项目(BS2007047)

摘　　要：目的:探讨补体因子H(CFH)基因1277T/C多态性与早发冠心病的相关性。方法:选择早发冠心病患者(男<55岁,女<60岁)125例、非冠心病对照组126例,收集研究对象临床资料,检测生化指标。采用聚合酶链反应-连接酶检测反应(PCR-LDR)分析CFH基因1277T/C多态性。结果:早发冠心病组吸烟、高血压病及糖尿病比例较对照组明显增多(P<0.05)。早发冠心病组与对照组CFH基因1277T/C中TT、TC、CC基因型频率分布差异无统计学意义(χ2=0.081,P>0.05)。结论:CFH基因1277T/C多态性可能与早发冠心病的易感性无关。Objective：To evaluate the role of complement factor H （CFH） gene ^127T/C polymorphism in premature coronary heart disease （CHD）. Methods：251 patients （〈55yr in male and 〈60yr in female） were divided into two groups. 125 cases were labeled as premature CHD group. 126 subjects were labeled as controls. Clinic data were collected. Polymerase chain reaction-ligase detection reaction （PCR-LDR） was used to analyze CFH gene ^127T/C polymorphism. The frequency distribution of CFH gene ^127T/C polymorphism was analysed between the Premature CHD group and the control group. Results：The proportion of cigarette smoking ,hypertension and familial history of diabetes mellitus in patients of the premature CHD group was higher than that in patients of the control group （P〈 0.05）. No difference was found according to the frequency distribution of CFH gene ^277T/C polymorphism TT,TC,CC between the two groups（x^2=0.081 ,P〉0.05）. Conelutions ：The gene ^127T/C polymorphism of CFH may be innocent to susceptibility of premature CHD.

关 键 词：补体因子H 基因多态性 早发冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]