依达拉奉对创伤性脑损伤大鼠脑保护作用的实验研究  

Neuroprotective effects of the edaravone in rats with traumatic brain injury

作　　者：马宝君[1] 李永财[1] 王勇[1] 汪志峰[1] 虞昊[1] 

机构地区：[1]南通大学第二附属医院神经外科,江苏226001

出　　处：《交通医学》2008年第6期620-622,共3页Medical Journal of Communications

基　　金：南通市社会发展计划项目(编号S5031)

摘　　要：目的:研究依达拉奉对大鼠创伤性脑损伤(TBI)的脑保护作用。方法:SD雄性大鼠50只,随机分为假手术组、对照组、依达拉奉低剂量组(0.75g/kg)、中剂量组(1.5mg/kg)、高剂量组(3.0mg/kg),每组10只。采用改良的Feeney法建立大鼠TBI模型,手术后24h测定大鼠神经行为学评分、脑含水量、血脑屏障通透率,术后72h观察组织形态学改变。结果:与对照组相比,依达拉奉低、中、高剂量组均能改善TBI后大鼠神经行为学障碍,降低脑水肿程度,抑制血脑屏障的破坏,同时逆转组织病理学改变;依达拉奉高剂量组治疗效果更明显。结论:依达拉奉对于TBI大鼠具有明显的脑保护作用。Objective： To investigate the protective effect of edaravone aganist traumatic brain injury （TBI） in rats. Methods： 50 male Sprague-Dawley rats were randomly divided into five groups, sham-operation group, vehicle group and edaravone therapy group （including low, middle, and high dose groups）. The modified Feeney＇s method was employed to establish TBI model in rats. The neurology deficit score, brain water content and permeability of blood-brain barrier （BBB） were measured 24 hours after TBI, while the histopathological damage was detected by Nissl staining 72 hours after TBI. Results： Compared with the vehicle group, edaravone dose-dependently decreased the neurology deficit score, reduced the brain water content and permeability of BBB. Furthermore, edaravone restrained neuronal loss and necrosis in the hippocampus. Among three doses, edaravone high-dose group showed the best therapeutic efficacy. Conclusions： These results suggest that edaravone exerted a neuroprotective effect on the brain after TBI in rats.

关 键 词：依达拉奉 创伤性脑损伤 血脑屏障通透率 海马 神经保护 

分 类 号：R651.15[医药卫生—外科学]