克林沙星的吸附伏安特性及其应用  

Adsorptive Voltammetric Behavior of Sparfloxacin and Its Application

作　　者：祝保林[1] 高锦红[1] 李吉锋[1] 

机构地区：[1]渭南师范学院化学化工系,陕西渭南714000

出　　处：《青岛科技大学学报（自然科学版）》2008年第6期485-489,共5页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：陕西省教育厅专项科研计划资助项目(06JK303)

摘　　要：在0.2 mol.L-1KH2PO4-K2HPO4(pH6.80)底液中,克林沙星(CF)在汞电极上有一线性扫描还原峰,峰电位Ep=-1.46 V(vs.Ag/AgCl),该峰说明汞电极对克林沙星具有明显的吸附性。测得CF在汞电极上的饱和吸附量sГ=4.82×10-11mol.cm-2,每个CF分子所占电极面积为2.64 nm2,CF在汞电极上的吸附符合Langmuir吸附等温式。测得吸附系数β=1.06×106,25℃时的吸附自由能ΔGθ=-32.13 kJ.mol-1,电极反应电子数n=2,不可逆体系动力学参量αna=1.44,表面电极反应速率常量ks=0.26 s-1。建立了吸附溶出伏安法测定CF的最佳条件,方法的检出限为2.0×10-8mol.L-1。In a supporting electrolyte of 0.2 mol · L^ -1KH2PO4-K2 HPO4 （pH 6.80）, a reduction peak of clinafloxaein （CF） with a potential of --1.46 V （vs. Ag/AgCl） and adsorptive characteristics was observed by linear scanning voltammetry at Hg electrode. The obtained results showed that the saturated adsorption amount of CF on Hg electrode was 4.82 ×10^-11 mol· cm^-2 and the area occupied by each CF molecule was 2.64 nm^2. The adsorption obeys Langmuir adsorption isotherm. The adsorption coefficient β, Gibbs energy of adsorption △G^θat 25 ℃ ,the number of electrons transferred n, kinetic parameter of the irreversible system ano and the rate constant of surface electrode reaction ks are 1.06×10^6, --32.13 kJ·mo1^-1, 2,1.44 and 0.26 s^-1 respectively. The optimum conditions for detecting CF by adsorptive stripping voltammetry was proposed and the detection limit was 2. O×10^-8 mol·L^-1.

关 键 词：克林沙星 吸附溶出伏安法 电化学行为 药物分析 

分 类 号：O647.3[理学—物理化学]