纳洛酮治疗重度酒精性昏迷的临床及数量化脑电图分析  

Clinical and quantitative electroencephalogram analysis of naloxone treatment on severe alcohol intoxication-induced coma.

作　　者：王天昊[1] 樊双义[1] 马朋林[1] 

机构地区：[1]解放军总医院第二附属医院急诊科,北京100091

出　　处：《四川医学》2008年第12期1615-1617,共3页Sichuan Medical Journal

摘　　要：目的探讨不同剂量纳洛酮治疗急性重度酒精昏迷患者的临床疗效及其与数量化脑电图的相关性。方法将重度酒精昏迷患者80例随机分为4组,每组20例。N1:对照组;N2:0.4mg纳洛酮组;N3:0.8mg纳洛酮组;N4:0.8mg纳洛酮重复组。测定4组患者血压、呼吸达到平稳的时间及清醒时间,同时测定用药后0.5、2、4h 4组患者BIS值。结果纳洛酮组血压、呼吸稳定时间比对照组短(P<0.05),N4疗效优于N2(P<0.05);大剂量纳洛酮组清醒时间比对照组短(P<0.01)。用药2、4h后N3、N4 BIS值与对照组均有统计学意义(P<0.01)。结论大剂量纳洛酮给药能有效改善重度酒精昏迷的临床表现并引起相应脑电图指标变化,数量化脑电图可用于监测酒精性昏迷程度及用药效果。Objective To investigate the effect of naloxone under different dose on treatment of acute alcohol intoxication-induced coma and the correlation between clinical manifestation and QEEG（ quantitative electroencephalogram）. Methods 80 severe alcohol intoxication-induced coma patients were divided into 4 group randonfly, 20 cases in each group. NI：control;N2：0.4mg naloxone;N3 ： 0.8mg naloxone;N4：0.8mg naloxone repeatly.The duration time were measured when patients＇ BP/breath recover to stable state1 simultaneeusly,the value of BIS of 4 group were also measured at the the point of O. 5h,2h,4h after medicine given. Results The recovery time of BP/breath of naloxone group was less than that of control（ P 〈0.05）;the therapeutic effect of group N4 was better than that of N2（ P 〈 0.01 ） ;the awake duration of group N3/N4 was also less than that of group N1（ P〈 0.01 ）. Conclusion Large dose naloxone can relieve effectively the clinical symptom of severe alcohol coma and also induce relative variation of EEG data. QEEG can be used in monitoring the depth of alcohol coma and the effect of the medicine.

关 键 词：纳洛酮 酒精性昏迷 数量化脑电图 双频谱指数 

分 类 号：R595.6[医药卫生—内科学]