冠心病患者血清胆红素和氧化型低密度脂蛋白的相关性分析  

Study on the relationship between serum bilirubin and oxidized low density lipoprotein in patients with coronary heart disease.

作　　者：李贵星[1] 袁莉[1] 高宝秀[1] 黄志刚[1] 唐书强[1] 周君[1] 彭志勇[1] 

机构地区：[1]四川大学华西医院实验医学科,四川成都610041

出　　处：《四川医学》2008年第12期1702-1704,共3页Sichuan Medical Journal

摘　　要：目的分析冠心病(CHD)患者血清胆红素与氧化型低密度脂蛋白(oxLDL),探索胆红素和oxLDL与CHD的关系。方法分别收集80例经临床确诊的冠心病患者及80例无心血管疾病、糖尿病及肾病的健康人群的空腹血清。进行胆红素、oxLDL及常规血脂[包括三酰甘油(TG)、胆固醇(Chol)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)]分析。结果CHD组和对照组比较,两组的TG、Chol、HDL-C、LDL-C及oxLDL无差异;CHD组血清胆红素水平低于对照组(P<0.05);CHD组oxLDL/LDL比值明显高于对照组(P<0.05)。结论和传统的血脂分析比较,血清oxLDL/LDL比值将为冠心病患者的诊断、治疗及预后评估提供更好的帮助,有望成为评价CHD危险因素更灵敏有效的血液生化指标。Objective To study the relationship between oxidized low density lipoprotein（oxLDL） and serum bilirubin in patients with coronary heart disease（CHD）.Methods Collection 80 serums of patient with coronary heart disease（CHD） and 80 normal controls with no cardiovascular disease,diabetes mellitus and nephrosis. Bilirubin,Tfiglyceride （TG）, Cholesterol（ Chol）, High density lipoprotein cholesterol（HDL-C）,Low density lipoproten-cholesterol（LDL-C）,oxLDL were detected. Results The ratio of oxLDL/LDL was significantly higher in CHD group than controls and bilirubin was significantly Lower than those of controls（ P〈 0.05）.while the levels of oxLDL, Chol, TG, LDL, HDL, Bilirubin were no difference between patient of CHD with normal controls （ P 〉 0.05）. Conclusion There were no difference on TG, Chol, HDL, LDL, oxLDL between CHD with normals, The ratio of oxLDL/LDL was were significantly higher than those of controls（ P 〈 0.05） and bilirubin was significantly lower than those of controls, the ratio of oxLDL/LDL can be more sensitive marker and more operative than routine lipid marker for evaluating CHD.

关 键 词：动脉粥样硬化 氧化型低密度脂蛋白 胆红素 

分 类 号：R541.4[医药卫生—心血管疾病]