羟基磷灰石及其聚合物复合材料在眼科的应用  

Ophthalmic applications of hydroxyapatite and its polymer composites

作　　者：廖洪斐[1] 肖卫[1] 陈蔷娟[1] 

机构地区：[1]南昌大学第一附属医院眼科,江西省南昌市330006

出　　处：《中国组织工程研究与临床康复》2008年第45期8905-8908,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：江西省卫生厅基金资助项目(G010507)~~

摘　　要：羟基磷灰石作为一种生物活性材料,与人体硬组织中的无机物结构、成分相同,其生物相容性、界面生物活性优于其他生物材料。羟基磷灰石在眼窝重建、眼眶重建、人工角膜移植及药物载体方面已得到广泛的应用。纯粹的羟基磷灰石在应用中存在脆性大,材料的抗弯强度低,在生理环境中的抗疲劳与抗破坏强度低等缺陷。将羟基磷灰石制成多孔或与其他物质组合制成复合材料可克服这些缺点,使羟基磷灰石的临床应用范围扩大。随着各种复合材料性能优化的方法和途径的发展以及制备工艺的优化,羟基磷灰石及其聚合物组织工程材料在眼科的应用也将得到进一步发展。Hydroxyapatite, as a biologically active material, has the same structure and ingredients as the inorganic of hard tissue in human body, moreover, its biocompatibility and biological activity of interface are better than other biological materials. Hydroxyapatite has been widely used in anophthalmus reconstruction, orbital reconstruction, artificial cornea transplant and drug carrier. Pure hydroxyapatite has some defects such as brittleness, low-bending strength, the strength of anti-fatigue and anti-sabotage in the physical environment are not high. In order to overcome or reduce these shortcomings, porous hydroxyapatite and composite hydroxyapatite are made to extent the clinical application of hydroxyapatite. With a variety optimization of performance, process and preparation of the composite materials, the hydroxyapatite/polymer tissue engineering materials in ophthalmology will be further developed.

关 键 词：羟基磷灰石聚合物 眼窝重建 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]