药物体外吸收、分布、代谢和排泄筛选模型  

A screening model of drug absorption,distribution,metabolism and excretion in vitro

作　　者：王琳[1] 陈涵[1] 

机构地区：[1]甘肃省康复中心医院,甘肃省兰州市730000

出　　处：《中国组织工程研究与临床康复》2008年第50期9957-9961,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：药物在吸收、分布、代谢和消除过程中具有良好的药代动力学性质和较低的毒副作用是候选药物通过临床试验的关键所在。这就需要合理的体外模型来对药物的体内行为进行预测。总结已有的、用于研究药物的吸收、分布、代谢、消除和药物毒性,基于细胞水平的体外模型。目前药物肠吸收的模型主要有动物体内实验和使用人造细胞膜、细胞系及肠组织的体外实验;药物分布模型包括药物与血清蛋白结合模型、药物向各组织分布的模型及透血脑屏障模型;药物代谢包括代谢稳定性、药物相互作用及药物毒性几方面。The pharmacokinetics and side effect in the process of absorption, distribution, metabolism and excretion （ADME） are the key points in increasing the speed of nomination of likely clinical candidates drugs clinical, which needs to early predicted by the situation in vivo through in vitro models. This paper takes a summary of in vitro models at cell levels in investigating drug properties in ADME and toxicity. So far, construction has three major modes： intestinal absorption model, which contains animal in vivo experiments, and in vitro test with artificial membrane/cell line or intestinal tissue. The drug disposition models, including drug combined with serum protein model, drug disposition and blood brain barrier model. The drug metabolism models consist of metabolic stability, drug interaction and drug toxicity model.

关 键 词：吸收 分布 代谢 排泄 筛选模型 药物 

分 类 号：R318[医药卫生—生物医学工程]