三七总皂苷对心梗后心室重构大鼠血流动力学作用  

Effects of Panax Notoginsenoside on Hemodynamics in Rats with Post-myocardial Infarction-ventricular Remodeling

作　　者：郭洁文[1] 邓志军[2] 符永恒[3] 杨敏[3] 李丽明[1] 潘竞锵 

机构地区：[1]广州市中医医院,广东广州510130 [2]广州中医药大学,广东广州510405 [3]广东省人民医院医学研究中心/广东省心血管病研究所,广东广州I510080 [4]广州市中医中药研究所,广东广州510130

出　　处：《中药材》2008年第12期1862-1865,共4页Journal of Chinese Medicinal Materials

基　　金：广东省社会发展领域科技计划项目(83100);广东省中医药管理局基金资助项目(1060060、2008005);广州市中医药中西医结合科研项目(2008A15)

摘　　要：目的:研究三七总皂苷(PNS)对急性心肌梗塞(AMI)后左室重构(LVRM)大鼠血流动力学的影响。方法:结扎大鼠左冠状动脉前降支建立AMI模型,术后24 h随机分为对照组和实验组,连续4w分别灌胃给予生理盐水和PNS低、中、高剂量,观察PNS对病鼠心脏冠脉流量(CF)、左心室收缩压(LVSP)、左心室舒张末期压(LV-EDP)、左心室舒张压(LVDP)、等容收缩期左心室内压最大上升和下降速率(±dp/dtmax)、左心室收缩峰压(LVPP)、左室收缩速度(VPM)等心功能变化指标及心肌细胞病理结构和心脏指数改变的影响。结果:PNS可显著提高病鼠LVSP、CF、VPM及±dp/dtmax(P<0.01或P<0.05),显著降低LVEDP及LVPP(P<0.01或P<0.05),能显著改善病鼠左室心肌细胞形态结构的病理改变及心脏指数(P<0.01)。结论:PNS可通过扩张冠脉血管增加病鼠心脏冠脉流量,降低冠脉阻力,调整室壁顺应性,减轻心肌细胞结构病理损伤,明显改善左心收缩和舒张功能,对AMI后心脏血流动力学有改善作用。Objective ：To research the function of Panax Notoginsenoside （PNS） on hemodynamics in rats with acute myocardial infarction-left ventricular remodeling（AMI-LVRM）. Methods：rat models of AMI were built by ligating left anterior descending coronary artery. After 24 hours of postoperative in rats, the rats were randomly divided into model group, shame groap and the low, middle and high dosage of PNS groups. After four consecutive weeks＇ treatment, We observed the cardiac function index such as Coronary flow （CF）, Left ventricular systolic （LVSP）, Left ventricular end-diastolic pressure （LVEDP）, Left ventricular diastolic blood pressure （LVDP） , maximal rising and falling rate of ventricular pressure （ ± dp/dtmmax ） , Left ventricular systolic peak pressure （ LVPP ） , Left ventricular systolic velocity（VPM） and the pathological structure of cardiac myocyes, cardiac index of PNS in the disease rats. Results ： Compared with the model group, PNS could significantly increase LVSP, CF, VPM, ± dp/dtmax （ P 〈 0. 01 or P 〈 0. 05 ）, and decrease LVEDP and LVPP（P 〈0. 01 or P 〈0. 05）. PNS could significantly improve pathological changes and cardiac index of left ventricular cardiac myocytes＇morphology rats （P 〈 0. 01 ）. Conclusion：By increasing the disease rats＇coronary blood flow and improving the compliance of ventricular wall, PNS can reduce pathological injury of cardiac myocytes and significantly improve systolic and diastolic function in AMI-LVRM.

关 键 词：三七总皂苷 心肌梗塞 左室重构 血流动力学 

分 类 号：R285.5[医药卫生—中药学]