男性尖锐湿疣患者的异性性伴侣HPV感染监测及早期干预  

HPV infection monitoring and early interfering of sexual partners of male CA patients

作　　者：杨文林[1] 杨健[1] 张红娟[1] 黄新宇[1] 

机构地区：[1]广州医学院第二附属医院皮肤科,广东广州510260

出　　处：《岭南皮肤性病科杂志》2008年第6期324-326,共3页Southern China Journal of Dermato-Venereology

基　　金：广东省医学科研基金资助项目(项目编号:A2006300)

摘　　要：目的:调查男性尖锐湿疣患者的异性性伴侣HPV感染率,并通过早期干预以期阻断女性尖锐湿疣发生和HPV持续感染状态。方法:采用前瞻性方法研究男性尖锐湿疣患者的异性性伴侣发生尖锐湿疣、HPV亚临床感染及潜伏感染的情况,通过性行为干预和早期局部治疗尖锐湿疣和HPV亚临床感染,并观察干预效果。结果:入选的120对病例,男性尖锐湿疣的异性性伴侣尖锐湿疣的发生率为35.8%,HPV亚临床感染率18.3%,子宫颈HPV潜伏感染发生率为25.0%;通过早期治疗和性行为干预,干预组受试者接受干预后尖锐湿疣/HPV感染发生率比对照组低,其差异有统计学意义(P<0.01)。结论:对男性尖锐湿疣患者的性伴侣进行早期治疗和干预,能有效预防尖锐湿疣的传播,对控制性传播疾病的蔓延具有重要意义。Objective ： To investigate the rate of human papilloma virus （HPV） infection of the sexual partners of the male with condyloma acuminatum（ CA）, and attempt to block the incidence and HPV persistent infection in women by early interfering. Methods： The sexual partners of males with CA were recruited, the incidence of CA, HPV subclinical infection and latent infection were investigated. The patients also received counselling on sexual behavior and an early treatment of CA. Results：Totally 120 women were observed, the incidence of CA was 35.8%, the subclinical infection of HPV was 18.3%, the HPV infection in cervix was 25.0%. After early treatment and sexual behavior interfering, the incidence of CA and HPV infection in the interfering group was lower than that in the controls, the difference was significant （P 〈 0. 01 ）. Conclusion：Early sexual behavior counselling and treatment in the sexual partners of male with CA can be effective in preventing the spread of CA and is of great significance in controlling the spread or sexually transmitted diseases.

关 键 词：尖锐湿疣 人乳头瘤病毒 干预 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]