超声消融联合干细胞移植治疗下肢动脉硬化性闭塞症的临床研究  

Ultrasound ablation combined with autologous transplantation of bone marrow mononuclear cells for treatment of arteriosclerosis obliterans

作　　者：王寅冬[1] 王爱林[1] 

机构地区：[1]黑龙江省医院周围血管病科,黑龙江哈尔滨150036

出　　处：《中国普通外科杂志》2008年第12期1164-1166,共3页China Journal of General Surgery

摘　　要：目的观察血管内超声消融联合自体骨髓干细胞移植治疗下肢动脉硬化性闭塞症的疗效。方法分析39例下肢动脉硬化性闭塞症的患者行血管内超声消融联合自体骨髓干细胞移植治疗的临床资料。男21例,女18例;平均年龄63岁。手术首先抽取自体骨髓260mL,分离出单个核细胞,制备干细胞悬浊液40mL。采用经皮股动脉穿刺或切开显露,经股浅动脉上部向下插入超声消融导管,在动脉造影监视下进行血管内超声消融,尔后将干细胞悬浊液一次性分点注射于小腿缺血肌肉内局部。结果39例患者术后静息痛缓解,跛行距离增加,冷、凉感觉得到改善。结论血管内超声消融联合自体骨髓干细胞移植治疗下肢动脉硬化性闭塞症是一种简便、有效的方法。Objective To investigate the efficacy of ultrasound ablation combined with autologous transplantation of bone marrow mononuclear cells in treatment of arteriosclerosis obliterans. Methods Clinical data of 39 patients with arteriosclerosis obliterans treated with ultrasound ablation and autologous transplantation of bone marrow mononuclear cells were analyzed. There were 21 male and 18 female patients, With average age of 63 years. At operation, 260 mL of autologous bone marrow was withdrawn, mononuclear cells were separated, and dO mL supension fluid of stem cells was prepared. Through percutaneous approach or surgical approach the ultrasound ablation catheter was inserted into occluded arterial segments. After ablation was performed, autologous bone marrow mononuclear cells were directly injected into the skeletal muscles of the ischemic leg. Results No complications were found in this group. Postoperatively, rest pain of all the patients was significiently improved and distance of claudieation increased. The skin became warm in all legs. Conclusions Ultrasound ablation and autologous transplantation of bone marrow mononuclear cells is a simple, safe and effective method for treating patients with arteriosclerosis obliterans.

关 键 词：动脉闭塞性疾病/治疗 超声消融 骨髓 干细胞移植 

分 类 号：R658.3[医药卫生—外科学]