婴幼儿反复呼吸道感染与胃食管反流关系的临床研究  

Clinical study on respiratory infection and gastroesophageal reflux in infants and children

作　　者：陆建红[1] 徐美玉[1] 吴惠芳[1] 盛俞[1] 顾健辉[1] 倪松石[2] 

机构地区：[1]南通大学附属医院儿科,江苏南通226001 [2]南通大学附属医院呼吸内科,江苏南通226001

出　　处：《同济大学学报（医学版）》2008年第6期117-120,共4页Journal of Tongji University(Medical Science)

摘　　要：目的为探讨婴幼儿呼吸道感染反复发作或迁延不愈与胃食管反流(gastroesophageal reflux,GER)的关系。方法我们对42例呼吸道感染反复发作或迁延不愈的婴幼儿进行了24 h食管pH监测,监测指标包括pH<4的次数、反流持续时间≥5 min的次数及最长反流持续时间、24 h总、立位和卧位食管pH值<4的时间占总监测时间的百分比和Boix-Ochoa综合评分。结果42例中存在胃食管反流22例(占52.4%),其中14例患儿经抗反流治疗后咳喘持续时间和肺部罗音消失时间均较未用抗反流治疗者短,差异有统计学意义(P<0.05),治疗后复测24 h食管pH,各项食管酸反流监测所示异常的指标均较治疗前有明显下降,差异有统计学意义(P<0.05)。结论婴幼儿呼吸道感染反复发作或迁延不愈常合并胃食管酸反流,两者之间有密切关系;认识婴幼儿呼吸道感染反复发作或迁延不愈与胃食管反流的关系,及时调整治疗方案,对预防和治疗该类疾病有积极意义。Objective To study the relationship between recurrent or protracted respiratory infection with gastroesophageal reflux （GER） in infants and children. Methods A twenty-four hour esophageal pH monitoring was performed in 42 patients with recurrent or protracted respiratory infections. The numbers of pH 〈 4, the numbers of reflux lasting for longer than 5 minutes, the duration of the longest episode of reflux, the percentage of time of pH 〈 4 in the total period and the score of Boix-Ochoa were recorded. Results Twenty-two （22, 52.4% ） of 42 children had pathological GER. The duration of cough, asthma and the presence of rale heard in lungs were significantly shorter in 14 GER patients with anti-reflux treatment than others without anti-reflux treatment （ P 〈 0.05 ）. All acid reflux indexes were significantly lower after anti- reflux therapy as showen by twenty-four hour esophageal pH monitoring. Conclusion GER is common in infants and children with respiratory infections, there is an intimate association between them. Realizing the relationship between recurrent or protracted respiratory infections and gastroesophageal reflux and adjusting therapy strategy are beneficial for this kind of disease.

关 键 词：呼吸道感染 胃食管反流 婴幼儿 

分 类 号：R725.6[医药卫生—儿科]