狼疮性肾炎肾脏病理活动指数与临床指标之间关系的探讨  

Relationship between pathologic activity index and clinical active index in lupus nephritis

作　　者：马增伟[1] 赵阴环[2] 

机构地区：[1]齐齐哈尔医学院附属第三医院肾内科,黑龙江齐齐哈尔161000 [2]哈尔滨医科大学第二临床医学院风湿科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2008年第6期641-644,共4页Journal of Harbin Medical University

摘　　要：目的分析狼疮性肾炎(LM)临床症状及实验室检查与肾脏病理活动性指数(AI)之间的关系,为临床治疗提供参考依据。方法将99例患者分为两组,A组(LN活动组)AI≥6分,B组(LN非活动组)AI<6分。分析病理类型、相关LN临床指标与AI的关系。结果A组病理类型以Ⅳ型LN最多,占59.02%,B组病理类型以Ⅱ型最多,占57.89%,Ⅳ型LNAI积分及SLEDIA评分最高,A组发生肾病综合征、高血压、肾功能损伤、抗ds-DNA抗体滴度升高、补体C3、C4降低、低白蛋白血症、近期血肌酐升高、肉眼或新出现血尿、尿蛋白定量≥1 g/24 h的阳性率明显高于B组(P<0.05)。结论临床症状及实验室检查可以作为判定LN活动性的临床指标,用来评估肾脏损害的程度,指导临床治疗。Objective To analyze the relationship between clinical symptom, laboratory results and pathologic activity index （AI） in lupus nephritis （LN）, and provide guidance for the clinical treatment. Methods Ninety nine patients were divided into 2 groups： Group A was in the active phases of lupus nephritis （AI≥6）,group B was in the non-active phases of lupus nephritis （AI 〈6）. The relation was analyzed between AI and pathologic types as well as clinical indexes related to LN. Results Type IV of LN were showed at most in group A （59.02%） and Type Ⅱ at most in group B （57.89%） according to pathologic type. The highest AI integral and SLEDIA score were showed in Type IV of LN. The positive rates in group A were significantly higher than that in group B （ P 〈 0.05 ） of happening nephrotic syndrome, hypertension, declined renal function, increased＇ titer of anti dsDNA antibodies, decreased complement C3 or C4, hypoalbuminemia, increased creatinine, gross hematuria, urine protein quantity 〉 1 g/24 h. Conclusion Clinical symptom and laboratory results can be used in decision of LN activity, estimation of renal damage degree and guiding clinical treatment.

关 键 词：狼疮性肾炎 肾活检 实验室检查 

分 类 号：R593.24[医药卫生—内科学]