过敏原检测在诊断过敏性鼻炎和支气管哮喘中的意义  

Diagnostic significance of serum allergen detection in diagnosis of allergic rhinitis and bronchial asthma

作　　者：樊春红[1] 杨铁生[1] 唐素玫[1] 王琴[1] 张正[1] 

机构地区：[1]北京大学人民医院检验科,100044

出　　处：《中华医学杂志》2008年第48期3422-3424,共3页National Medical Journal of China

摘　　要：目的分析总IgE、吸入性过敏原过筛（Phadiatop）、嗜酸性阳离子蛋白（ECP）和特异性IgE（SIgE）检测在诊断过敏性鼻炎和支气管哮喘中的意义。方法回顾性分析122例过敏性鼻炎患者血清Phadiatop、SIgE、总IgE水平；135例支气管哮喘患者血清Phadiatop、SIgE、ECP水平；以40名健康体检者为对照。结果过敏性鼻炎患者血清总IgE阳性率37．7％，高于正常对照组（2．5％，χ^2=18．13，P〈0．01），特异性97．5％；支气管哮喘患者的血清ECP阳性率65．9％，高于正常对照组（20．0％，χ^2=26．34，P〈0．01），敏感性65．9％，特异性80．0％。过敏性鼻炎和支气管哮喘患者Phadiatop阳性率分别为50．0％和31．9％，显著高于正常对照组（0，χ^2=32．08、16．89，均P〈0．01）。最常见的SIgE均为户尘螨、粉尘、蒿、艾蒿等。结论ECP含量的升高是诊断支气管哮喘患者呼吸道炎症的重要指标；总IgE在过敏性鼻炎的诊断有重要的临床意义；Phadiatop及SIgE阳性的检出在过敏性鼻炎和支气管哮喘患者中的诊断监测中有重要的意义。Objective To analyze the diagnostic significance of serum total IgE, specific IgE （SlgE）, Phadiatop, and eosinophil cationic protein （ECP） in allergic rhinitis and bronchial asthma. Methods The serum total IgE, SIgE , and Phadiatop were tested in 122 patients with allergic rhinitis. The ECP, SIgE , and Phadiatop were tested in 135 patients with bronchial asthma. Forty healthy persons were used as controls. The serum total IgE were tested by electrochemiluminescence . The serum Phadiatop, ECP, and SIgE were tested by fluorescent-enzyme linked immunosorbent assay. Results The serum total IgE positive rate of the 122 allergic rhinitis patients was 37.7%, significantly higher than that of the healthy controls （2. 5%, χ^2 = 18. 13 ,P 〈 0. 01 ）. The specificity of total IgE of the allergic rhinitis patients were 97.5%. The serum ECP positive rate of the bronchial asthma patients was 65.9%, significantly higher than that of the healthy controls （ 20. 0% , χ^2 = 26. 34, P 〈 0. 01 ）. The sensitivity and specificity of the bronchial asthma patients were 65.9% and 80. 0%. The Phadiatop positive rates of the allergic rhinitis and the bronchial asthma patients were 50. 0% and 31.9% respectively, both significantly higher than that of the control （0, χ^2 =32. 08, 16. 89, both P 〈0. 01 ）. Most kinds of SIgE were from the allergens, such as dust mite, dust, and Artemisia etc. Conclusion Increase of serum ECP level is an important indicator of airway inflammation activity and inflammation serious degree in the bronchial asthma patients. The increase of serum total IgE has an important diagnostic significance in allergic rhinitis. It is important to detect SIgE and Phadiatop in diagnosis and monitoring of allergic rhinitis and bronchial asthma.

关 键 词：鼻炎 变应性 常年性 哮喘 IGE 嗜酸性阳离子蛋白 

分 类 号：R686[医药卫生—骨科学]