仙灵骨葆胶囊改善精液质量的临床研究  

Xianling Gubao Capsule Improves Semen Quality

作　　者：蒋敏[1] 韩字研[1] 岳焕勋[1] 李福平[1] 林丽[1] 佘文静[1] 

机构地区：[1]四川大学华西第二医院人类精子库,四川成都610041

出　　处：《中华男科学杂志》2008年第12期1146-1148,共3页National Journal of Andrology

摘　　要：目的：观察仙灵骨葆胶囊改善男性不育患者精液质量的情况。方法：女方生育功能正常的男性不育患者66例，口服仙灵骨葆胶囊2～4个月，观察治疗前后精液质量并进行精子形态学分析。结果：治疗2个月后，精子密度有所提高，但无统计学差异（P〉0．05）；精子存活率和活动率也无明显变化（P〉0．05）；治疗后正常形态精子百分率明显升高，其中正常形态精子百分率≥15％者，由治疗前的25．8％（17／66）增加为57．6％（38／66）（P〈0．05），而正常形态精子百分率〈9％者，由治疗前的53．0％（35／66）下降为25．8％（17／66）；7例少精子症者用药前精子正常形态百分率平均为5．8％，服药4个月后平均为10．9％，与服药前有明显差异（P〈0．05）。治疗期间有5例患者配偶怀孕。结论：仙灵骨葆胶囊对男性精液质量有改善作用，能明显提高正常形态精子百分率，少精子症者更明显。Objective： To observe the effect of the compound Chinese traditional drug Xianling Gubao Capsule on the semen quality of infertile males. Methods： We treated 66 infertile men with Xianling Gubao Capsule for 2-4 months, and analyzed the semen quality and sperm morphology before and after the treatment. Results： Two months after the medication, sperm concentration was increased by a small margin, but no statistically significant changes were observed in sperm vitality and motility （P 〉 0.05 ）, the rate of morphologically normal sperm was significantly raised from 25.8% before treatment to 57.6% （ P 〈 0.05 ） in those with the normal rate ≥15%, but decreased from 53.0% to 25.8% （ P 〈 0. 05 ） in those with the normal rate 〈 9%. Among the 7 cases of oligospermia, the rate of morphologically normal sperm was elevated to an average of 10.9% after the 4-month medication, significantly different from the baseline rate of 5.8% （P 〈 0.05 ）. Five spontaneous pregnancies and 1 successful IVF-ICSI were achieved during the treatment. Conclusion： Xianling Gubao Capsule can improve semen quality and significantly increase the percentage of morphologically normal sperm.

关 键 词：男性不育 精子形态 中药 仙灵骨葆胶囊 

分 类 号：R285.5[医药卫生—中药学]