重度烧伤患者补充核黄素后营养状况的变化  

Change of Riboflavin Status Influenced by Supplementation of Riboflavin in Severely Burned Patients

作　　者：杨澎[1] 张明谏[2] 王其芳[2] 李小兵[2] 张静琦[2] 曹建功[2] 刘光晶[2] 刘子健 杨雷钧[2] 

机构地区：[1]天津医科大学一中心临床学院,300070 [2]天津市第一中心医院烧伤整形科

出　　处：《天津医药》2008年第12期948-950,共3页Tianjin Medical Journal

摘　　要：目的:对比观察重度烧伤患者补充核黄素后核黄素营养状况和血清总抗氧化水平的变化。方法:将入院治疗的重度烧伤患者随机分成补充核黄素组和未补充核黄素组,每组各30例。补充核黄素组患者于伤后第3天补充核黄素,每次口服(或经鼻胃管)核黄素10mg,每日3次,连续补充2周。分别于伤后1～3d、6～8d和13～15d,测定红细胞谷胱甘肽还原酶活性系数和血清总抗氧化能力。结果:重度烧伤患者补充核黄素后10～12d(即伤后第13～15天),补充核黄素组核黄素营养缺乏例数明显少于未补充核黄素组,差异有统计学意义(P<0.01);补充核黄素组患者血清总抗氧化水平高于未补充核黄素组(P<0.01)。结论:重度烧伤患者伤后2周内每日补充30mg核黄素能明显改善核黄素营养缺乏状况并能提高患者血清总抗氧化能力。Objective： To comparatively observe the changes of riboflavin status and serum total antioxidant capacity influenced by the supplementation of riboflavin in severely burned patients .Methods： Sixty severely burned patients were divided into riboflavin group （n=30） and without receiving riboflavin group （n=30） using stratified random sampling method. The patients treated with riboflavin 30 mg three times a day for two weeks. Erythrocyte glutathione reductase activation coefficient and the serum total antioxidant capacities in both groups were measured 1-3, 6-8, and 13-15 days postburn. Results： Number of riboflavin deficiency in patients receiving riboflavin was less than that in patients without receiveing riboflavin from day 13 to 15 postburn, and there was a significant difference （P 〈 0.05）. At the same time, the total antioxidant capacity levels in patients receiving riboflavin were higher than those in patients without receiving riboflavin （P 〈 0.01）. Conclusion： Riboflavin supplements （30 mg daily） were given to severely burned patients every day for two weeks, which can reduce the number of riboflavin deficiency and improve the total antioxidant capacity levels in severely burned patients.

关 键 词：烧伤 营养状况 核黄素 谷胱甘肽还原酶 红细胞 

分 类 号：R644[医药卫生—外科学] R977.22[医药卫生—临床医学]