铜/低密度聚乙烯纳米复合材料宫内节育器临床使用效果观察  

Clinical Acceptability of Copper/Low Density Polyethylene Nanocomposite IUD

作　　者：余晶[1] 李俊[1] 田红[1] 肖慧珠[1] 熊忠明[1] 谢长生[2] 朱长虹[1] 

机构地区：[1]华中科技大学同济医学院计划生育研究所,武汉430030 [2]华中科技大学材料学院,武汉430074

出　　处：《华中科技大学学报（医学版）》2008年第6期798-800,804,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家十一五科技支撑计划资助项目(No.2006BAI13B01)

摘　　要：目的以铜T型220C(TCu220C)宫内节育器(IUD)为对照,观察研究铜/低密度聚乙烯(Cu/LDPE)纳米复合材料IUD置器初期的临床使用可接受性。方法选择自愿放置Cu/LDPE纳米复合材料IUD或TCu220CIUD的已婚育龄妇女100例,随机分成2组,每组50例,分别放置Cu/LDPE纳米复合材料IUD和TCu220CIUD,并在置器后第1、3、6月随访观察,收集并研究分析临床效果和副反应。结果置器初期,Cu/LDPE纳米复合材料IUD产生令人满意的避孕效果,与TCu220CIUD比较,其所引起的经量增多、经期延长、淋漓出血、腰腹疼痛等副反应发生率低(P<0.05);置器前后血红蛋白值,支原体、衣原体感染率及B超监测子宫及附件病变发生率差异均无显著性意义(P>0.05)。结论Cu/LDPE纳米复合材料IUD用于人体宫内避孕可接受性良好。在置器初期引起的副反应低于TCu220CIUD,且无增加盆腔感染、致盆腔其他疾病及降低血红蛋白的趋势。Objective To compare acceptability in clinical application of Copper/low density polyethylene nanocomposite IUD （experimental group） and Copper T220C IUD （control group）. Methods 100 females were randomly divided into 2 groups （experimental group and control group, n= 50 in each group）. Clinical observation and comparative study were performed for 6 months. Results At the 6th month after insertion, Cu/LDPE nanocomposite IUD showed satisfactory contraception efficacy. The incidence of side effects such as large menstrual bleeding, spotting and pelvic pain was significantly lower than that of Copper T220C IUD （P〈0.05）. The level of Hb, infection rate of myeoplasma and Chlamydia or other pelvic diseases before and after IUD insertion were analyzed and no significant difference was found. Conclusion The new design of the Cu/LDPE IUD showed high contraceptive efficacy and satisfactory acceptability.

关 键 词：宫内节育器 副反应 

分 类 号：R169.412[医药卫生—公共卫生与预防医学]