维生素K_1注射乳在小鼠体内的药物分布评价  

In vivo distribution of vitamin K_1 emulsion for injection in mice

作　　者：吴悫[1] 邓意辉[1] 董晓辉[1] 石莉[1] 卢懿[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2009年第1期55-58,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备维生素K1注射乳,并考察其在小鼠体内的分布情况。方法采用微射流仪制备维生素K1注射乳;维生素K1注射乳剂和普通注射剂从尾静脉注射至小鼠体内,采用HPLC法测定维生素K1在小鼠体内各组织的浓度。结果维生素K1注射乳粒径为(172.2±63.0)nm,注射给药后,维生素K1注射乳组的肝、脾中维生素K1的AUC值分别为注射液组的2.34和2.70倍。结论维生素K1注射乳在小鼠体内具有显著肝、脾靶向性。Objective To prepare vitamin K1 emulsion for injection, and evaluate its in vivo distribution in mice. Methods Vitamin K1 emulsion for injection was prepared by microfluidizer treatment. The vitamin K1 emulsion and conventional vitamin K1 injection were administered into mice through tail-vein, and the drug concentrations in various tissues were determined by HPLC method. Results The resulted emulsion showed a mean diameter of（ 172.2±63.0） run. After the administration of emulsion formulation,the AUC values of vitamin K1 in liver and spleen were 2.34 and 2.70 times higher than conventional vitamin K1 injection, respectively. Conclusions The results show that vitamin K1 emulsion possessed better targeting ability to liver and spleen.

关 键 词：维生素K1 注射乳 组织分布 

分 类 号：R971[医药卫生—药品] R94[医药卫生—药学]