舌下含化硝苯吡啶快速降压作用疗效分析  

THERAPEUTIC EVALUATION OF QUICK ANTIHYPERTENSION OF SUBLINGUAL NIFEDIPINE

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作  者:马其民[1] 张旗[1] 张本荣[2] 

机构地区:[1]安徽省蚌埠市第二人民医院 [2]安徽省人民政府门诊部

出  处:《河北医学》1998年第2期1-3,共3页Hebei Medicine

摘  要:选择62例收缩期血压(SBP)26.67~37.3kPa,舒张期血压(DBP)16.0~18.67kPa高血压病患者。立即舌下含化硝苯吡啶20mg,观察该药短时间内快速降压效果,结果:30min内DBP下降2.67~3.33kPa者50例,占80.65%,60min内DBP下降1.33~3.6kPa及SBP下降3.33~10.93kPa者各58例,占93.55%。无效者4例,占6.45%。在治疗观察中,发现该药对充血性心力衰竭也有一定作用,12例心衰中经含化该药1~2h后,有9例(75%)患者临床症状得到明显改善,心率由原来平均101次/min,降至92次/min。由于该药具有扩张小动脉降低后负荷,同时也有扩张静脉作用,短时间降压速度快,可口服及舌下含化。因此,该药可作为重症高血压或高血压急症应急性药物,对并发有急性充血性心力衰竭患者也极为有益。In this paper,62 cases hypertensive patients were selected whose systolic pressure (SP) is 26.67~37.3Kpa and diastolic pressure (DP) is 16.0~18.67 Kpa,then they were given 20mg Nifedipine to observe the quick antihypertension effect in a short course.The result shows as follows.There were 50 cases whose DP had declined 2.67~3.33 Kpa in 30 min (80.65%) and 58 cases whose DP had declinded 1.33~3.6Kpa and SP declined 3.33~10.93 Kpa in 60 min (93.55%),only 4 cases no effect (6.45%).The observer also finds that nifedipine has some effect on congestive heart failure. In that the clinical symptoms of 9 cases heart failure patient is obviously improved of 12 cases patients after sublingually nifedipine 1~2 hours,whose heart rate declines from 101/min to 92/min.Generally,the drug can enlarge arteriole and vein to decline the afterload,So the antihypertension is quick.On the whole,the drug not only can act as emergency medicine for severe hypertension and hypertensive emergency,but also has much help for acute congestiue heart failure..

关 键 词:高血压 硝苯吡啶 心力衰竭 疗效 降压药 

分 类 号:R972.4[医药卫生—药品] R544.105[医药卫生—药学]

 

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