层次聚类法对周仲瑛哮喘病案方药量效关系的研究  

Effect of Hierarchical Method on Dosage-effect Relation in Prescriptions of ZHOU Zhong-ying for Treating Asthma

作　　者：李文林[1] 郭立中[2] 吴勉华[2] 程茜[2] 尚尔鑫[1] 

机构地区：[1]南京中医药大学江苏省方剂研究重点实验室,江苏南京210046 [2]南京中医药大学第一临床医学院,江苏南京210046

出　　处：《南京中医药大学学报》2009年第1期17-20,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家“十一五”科技支撑计划项目(2007BAI10B02);国家“十一五”科技支撑计划项目(2007BAI10B06-6);江苏省中医药局康缘中医药科技创新基金项目(HZ0801KY)

摘　　要：目的从量效关系的角度探讨周仲瑛治疗哮喘的用药特色。方法基于加权的层次聚类方法。结果处方中应用较多大部分补益药、清热药及止咳化痰平喘药的剂量范围在临床常规用量范围之内,但也有若干异常剂量药物的出现,如石斛、鱼腥草、茯苓等药物的用量均低于常规低剂量,葶苈子、泽漆、炒枳实等则高于临床常规用量。结论治疗哮喘方药的大部分剂量范围与《中华人民共和国药典》中记载的范围一致,但也有部分药物的剂量会因临床治疗需要而在一定的区间内调整。OBJECTIVE To explore into ZHOU Zhong-ying＇s features in using drugs to treat asthma by looking into the dosage-ef- fect relation. METHOD Weighted Hierarchical Clustering method was used. RESULT Most tonics, heat-clearing drugs and drugs for cough and asthma were used in conventional dosages, but there were some drugs that were used in abnormal dosages, such as Herba Dendrobii, Herba Houttuyniae Cordatae, Sclerotium Poriae Cocos, etc., whose dosages were lower than the conventional ones, and Semen Lepidii seu Descurainiae , Euphorbia helioscopia , Fructus Imunaturus Citri Aurantii , etc., whose dosages were above the conventional ones. CONCLUSION The dosages of most prescriptions for cough and asthnaa are with the dosage range stipulated in the Pharmacopeia of People＇ s Republic of China, though the dosage of part of the drugs should be regulated according to the need in clinical treatmcnt.

关 键 词：层次聚类 量效关系 周仲瑛 哮喘 用药剂量 

分 类 号：R249.7[医药卫生—中医临床基础]