血清蛋白质巯基水平在大鼠呼吸窘迫综合征发病时的变化  

Changes of serum protein-bound sulfhydryl level during development of respiratory distress syndrome in rats

作　　者：施红光[1] 李涛平[1] 彭道波[1] 

机构地区：[1]第一军医大学附属南方医院

出　　处：《当代医师》1998年第2期18-20,共3页

摘　　要：为进一步探索成人呼吸窘迫综合征（ＡＲＤＳ）的发病机理，本文以高浓度氧诱导大鼠肺损伤作为ＡＲＤＳ模型，观察动物氧暴露过程中血清蛋白巯基（Ｐ－ＳＨ）水平的变化。结果发现，动物氧暴露３０ｈ，肺组织出现典型的ＡＲＤＳ病理改变，同时发现血清Ｐ－ＳＨ水平显著下降（Ｐ＜０．０５）。提示，氧暴露大鼠ＡＲＤＳ的发生可能与体内Ｐ－ＳＨ的大量破坏有关。he present experiment was designed to further investigate the mechanism of adult respiratory distress syndrome (ARDS).Oxygen exposure of rats was performed to induce lung injury as a model of ARDS,during which,changes of serum protein-bound sulfhydryl (P-SH) level were observed.Results showed that the typical pulmonary pathologic changes of ARDS with decreased serum P-SH level were found in the rats exposed to oxygen for 30h.The result suggests that the development of ARDS in rats exposed to oxygen may relate to the impairment of P-SH.

关 键 词：成人 呼吸窘迫综合征 巯基 蛋白质 发病 

分 类 号：R563.8[医药卫生—呼吸系统]