庚型肝炎病毒RNA、NS_5抗原在肝组织中表达的研究  

EXPRESSION OF HGV RNA AND HGV NS_5 ANTIGEN IN LIVER TISSUES OF PATIENTS WITH VIRAL HEPATITIS

作　　者：辛绍杰[1] 王松山[1] 程云[1] 王林杰[1] 李静[1] 薛生 罗清华[1] 郭仁峰[1] 李伯安[1] 曹阳[1] 张建宗[1] 

机构地区：[1]解放军302医院,北京100039

出　　处：《中华肝脏病杂志》1998年第1期16-17,共2页Chinese Journal of Hepatology

摘　　要：目的研究 HGV RNA 及 HGV 抗原在肝组织中的表达。方法对17例 HGV 血清标志阳性患者进行了肝组织 HGV RNA 的原位杂交及免疫组织化学研究。结果原位杂交 HGV RNA 阳性8例,阳性率47.05%,阳性信号均存在于肝细胞的胞浆中;免疫组化3例 HGV NS_5抗原阳性,阳性率17.64%,均为胞浆型。结论 HGV RNA 及 HGV NS_5抗原阳性细胞及其周围肝细胞未见特殊病理改变。Objective To study the expression of hepatitis G virus (HGV) RNA and HGV NS5 antigen in the liver tissues.Methods The expression of HGV RNA and HGV NS_5 antigen in the liver tissues were detected with in situ hybridization and immunohistochemistry.Results The positive rate of HGV RNA and HGV NS_5 antigen expressed in the liver tissues were 47.05% and 17.64%,respectively. Conclusion The positive substances of HGV RNA and HGV NS_5 antigen were both in cytoplasm of the hepatocytes.The positive hepatocytes and the hepatocytes surrounding these positive cells have no specific pathologic changes.

关 键 词：庚型肝炎 原位杂交 免疫组化 HGV NS5抗原 

分 类 号：R512.63[医药卫生—内科学]