选择性雌激素受体调节剂母核结构的芳香烃亲电取代反应  

Electrophilic Substitution Reaction of Aromatic Hydrocarbon of the Mother Nucleus Structure of Selective Estrogen Receptor Modulators

作　　者：司玉昌[1] 张秋燕[1] 张力[1] 邓昌辉[1] 郭洪声[1] 

机构地区：[1]武警医学院基础部化学教研室,天津300162

出　　处：《安徽农业科学》2008年第34期14856-14858,共3页Journal of Anhui Agricultural Sciences

基　　金：武警总部;武警医学院院课题(WKH2004-2;WY2006-06)

摘　　要：设计了一类新型的氮正离子,探究N-酰基-N-烃氧基氮正离子与不同取代的芳香烃发生分子间的亲电取代反应。探讨了空间效应及电子效应对分子间亲电取代反应的影响,合成了可望作为选择性雌激素受体调节剂新母核的化合物。该类反应的深入研究为其在有机合成和药物合成及修饰方面奠定了理论和试验基础。A new type of nitrogen cations were designed.The electrophilic substitution reactions between N-acyl-N-alkoxy nitrogen cation and aromatic hydrocarbon with different substitutions were explored.The influences of spatial effect and electronic effect on the electrophilic substitution reaction among molecules were discussed.A compound that could be taken as the new mother nucleus of selective estrogen receptor modulators was synthesized.The further study on this type of reactions laid the theoretical and experimental foundation for the organic synthesis,pharmaceutical synthesis and modifications.

关 键 词：N-酰基-N-烃氧基氮正离子 亲电取代反应 雌激素受体调节剂 

分 类 号：R977.1[医药卫生—药品]