地高辛与奎尼丁及二氢奎尼丁协同对乳头肌动作电位时程的影响  

Effects of Digoxin with Quinidine and Dihydroquinidine on the Duration of Potential Action of Papillary Muscles in Guinea Pig

作　　者：叶丹[1] 蒋文平[1] 

机构地区：[1]苏州医学院附属第一医院心血管病研究室,215006

出　　处：《江苏医药》1998年第4期235-236,共2页Jiangsu Medical Journal

摘　　要：应用经典玻璃微电极方法研究地高辛与奎尼丁及二氢奎尼丁协同对豚鼠乳头肌动作电位复极30％（APD30）、复极50％（APD50）、复极90％（APD90）的影响。实验证明：10μmol／L，奎尼丁及二氢奎尼丁均使APD30、APD50、APD90明显延长（P＜0．05），加入6．4×10－4μmol／L地高辛后，均使延长的动作电位时程明显缩短，有正常化趋势（P＜0.05）。Conventional microelectrode technique was used to study the effects of digoxin with quinidine and dihydroquinidine on the duration of potential action of papillary muscles. It is concluded that 10μmol/L quinidine and dihydroquinidine could prolonged APD30, APD50 and APD90 (P<0. 05). Dixgoxin in the perfusate (6. 4 × 10-4μmol/L) could shorten the obviously prolonged APD(P<0. 05) in tendency to be normal.

关 键 词：奎尼丁 二氢奎尼丁 地高辛 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]